研究実績

論文

2019

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice.

Yuji Ueda, Koichi Kawamoto, Masamitsu Konno, Kozo Noguchi, Satoru Kaifuchi, Taroh Satoh, Hidetoshi Eguchi, Yuichiro Doki, Takaaki Hirotsu4, Masaki Mori and *Hideshi Ishii

Oncotarget. 2019; 10:5412-5418.(査読有)

2015

A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection

*Hirotsu T., Sonoda H., Uozumi T., Shinden Y., Mimori K., Maehara Y., Ueda N., Hamakawa M.

PLOS ONE, 10(3): e0118699(査読有)

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Hamakawa M., Deno Y., Nakajo M., *Hirotsu T.

Genes to Cells, 20, 802-816(査読有)

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.

Hamakawa M., Uozumi T., Ueda N., Iino Y, *Hirotsu T.

BMC Biology, 13:6(査読有)

Cancer screening test using C. elegans scent detection.

*Hirotsu T.

Aroma Research, 16, 134-136(依頼執筆)

2014

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.

Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., *Hirotsu T.

Science Signaling, 7 (323), ra39(査読有)

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.

*Hirotsu T.

Aroma Research, 15, 242-243(依頼執筆)

電位依存性アニオンチャネルVDAC-1は線虫C. elegansの嗅覚シグナル伝達において重要な働きを持つ

魚住隆行、出野結己、*広津崇亮

味と匂学会論文集, 21, 3 (査読有)

匂いの濃度に依存した嗅覚受容体の使い分け機構の解明

谷口群、濱川昌之、魚住隆行、桐山恵介、紙崎智子、*広津崇亮

味と匂学会論文集, 21, 3 (査読有)

2013

In vivo imaging of Ras protein’s activity in olfactory neurons.

Uozumi T., Yamada R., Suzuki A., Taniguchi G., Yoshida K., Iino Y., Ishihara T., *Hirotsu T.

Protocol Exchange, 2013, 011(依頼執筆)

2012

Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.

1Uozumi T., 1*Hirotsu T., Yoshida K., Yamada R., Suzuki A., Taniguchi G., Iino Y., and Ishihara T.

(Nature) Scientific Reports, 2, 500(査読有)

Odour concentration-dependent olfactory preference change in C. elegans.

Yoshida K., *Hirotsu T., Tagawa T., Oda S., Wakabayashi T., Iino Y., and Ishihara T.

Nature Communications, 3, 739(査読有)

Live imaging of signaling protein’s activity responding to odorant stimuli.

Uozumi T., *Hirotsu T

Aroma Research, 13, 244(依頼執筆)

Neural mechanisms of olfactory preference change depending on the odor concentration.

Yoshida K., *Hirotsu T.

Aroma Research, 13, 137(依頼執筆)

Scent aroma derived from woods: the consideration based on the physiological and psychological effects.

Shimizu K., Hirotsu T. (16人中8番目) et al.

線虫C. elegansにおける嗅覚受容体の網羅的解析

*広津崇亮、谷口群、桐山恵介、紙崎智子、佐藤則子、石原健

21世紀の遺伝学 VIII, 5(依頼執筆)

2011

Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans.

Shinkai Y., Yamamoto Y., Fujiwara M., Tabata T., Murayama T., Hirotsu T., Ikeda D., Tsunozaki M., Iino Y., Bargmann C., Katsura I., and Ishihara T.

Journal of Neuroscience, 31, 3007-3015

2010

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.

Yamada K., Hirotsu T., Matsuki M., Butcher A., Tomioka M., Ishihara T., Clardy J., Kunitomo H. and Iino Y.

Science, 329, 1647-1650(査読有)

2009

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.

Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H., Ishihara T., Iino Y. and Kubo T.

Nature Neuroscience, 12, 981-987(査読有)

Behavioural assay for olfactory plasticity in C. elegans.

Hirotsu T., Hayashi Y., Iwata R., Kunitomo H., Kage-Nakadai E., Kubo T., Ishihara T. and Iino Y.

Nature Protocols, 2009, 139(依頼執筆)

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.

Yamada K., Hirotsu T., Matsuki M., Kunitomo H. and Iino Y.

Genetics, 181, 1347-1357(査読有)

2008

線虫C. elegans における匂いの濃度に依存した行動変化を制御する神経回路の解明

吉田和史、*広津崇亮、飯野雄一、石原 健

21世紀の遺伝学 V, 5(依頼執筆)

2005

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.

Hirotsu T. and Iino Y.

Genes to Cells, 10, 517-530(査読有)

MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive neurites in Caenorhabditis elegans.

Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.

Current Biology, 15, 1554-1559(査読有)

2001
3月

学位論文線虫の嗅覚応答におけるRas-MAPK経路の機能に関する研究

広津 崇亮

(東京大学大学院 2001年3月)

2000

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.

Hirotsu T., Saeki S., Yamamoto M. and Iino Y.

Nature, 404, 289-93(査読有)

1999

Novel functions of the Ras-MAPK signal transduction pathway in neurons of C. elegans.

Hirotsu T., Saeki S. and Iino Y.

Worm Breeder's Gazette,15, 41(査読無)

国際プロシーディング

2014

The neural circuit mechanisms in the olfactory preference change after odor experience

Ueda N, Matsuo T, *Hirotsu T.

GENES & GENETIC SYSTEMS, 89, 335-335

2012

The Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M, Iino Y, *Hirotsu T.

GENES & GENETIC SYSTEMS, 87, 405-405

Systematic identification of the relationship between olfactory receptors and odorants in C. elegans

Taniguchi G, Kriyama K, Kamizaki T. *Hirotsu T.

GENES & GENETIC SYSTEMS, 87, 407-407

Identification of neural circuits of central olfactory adaptation in C. elegans

Matsuo T, *Hirotsu T

GENES & GENETIC SYSTEMS, 87, 408-408

2011

Best Paper賞受賞3D-03 Systematic identification of specific receptors for odorants in C.elegans

*Hirotsu T., Taniguchi G., Kiriyama K., Kamizaki T., Noriko Sato and Ishihara T.

GENES & GENETIC SYSTEMS, 86, 437-437

In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behaviour

Uozumi T., *Hirotsu T., et al.

Neuroscience Research, 71, E79-E79

Coordinated change of acting sensory neurons is important for olfactory preference change depending upon odor concentration

Yoshida K., *Hirotsu T., et al.

Neuroscience Research, 71, E174-E174

2009

Live imaging of Ras activity in olfactory neurons in C. elegans.

*Hirotsu T., Yamada R., Suzuki A. and Ishihara T.

Neuroscience Research, 65, S175-S175

Analysis of putative olfactory receptor genes in C. elegans.

Kiriyama K., *Hirotsu T., Kamizaki T., Noriko Sato and Ishihara T.

Neuroscience Research, 65, S175-S175

2008

Best Paper賞受賞Analysis of a neural circuit for the aversive response to high concentration of an attractive odorant in C. elegans.

Yoshida K., *Hirotsu T., Iino Y and Ishihara T.

GENES & GENETIC SYSTEMS, 83, 490-490

The neprilysin gene nep-2 is involved in olfactory adaptation in C. elegans.

Yamada K. Hirotsu T., Matsuki M. Kunitomo H. and Iino Y.

GENES & GENETIC SYSTEMS, 83, 490-490

G protein signaling in olfactory systems of C. elegans.

*Hirotsu T., Yamada R., Kamizaki T., Noriko Sato and Ishihara T.

Neuroscience Research, 61, S105-S105

2007

The neprilysin gene nep-2 is involved in olfactory adaptation in C. elegans.

Yamada K. Hirotsu T., Matsuki M. Kunitomo H. and Iino Y.

Neuroscience Research, 58, S216-S216

2006

Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans.

Hirotsu T. Ishihara T. Nishida E. and Iino Y.

Neuroscience Research, 55, S251-S251

Analysis of the significance and mechanism of neurite elimination using C. elegans as a model.

Hayashi Y., Hirotsu T., Kage E., Takeushi H., Kunitomo H., Iino Y. and Kubo T.

Neuroscience Research, 55, S185-S185

2004

A novel C. elegans transcription factor MBR-1 is involved in olfactory plasticity and axon pruning.

Hayashi Y., Kage E., Hirotsu T., Takeushi H., Kunitomo H., Iino Y. and Kubo T.

Zoological Science, 21, 1318-1318

The Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans.

Hirotsu T. and Iino Y.

Neuroscience Research, 50, S66-S66

Analysis of the function of MBR-1, a C. elegans transcription factor incolved in olfactory plasticity , in axon pruning.

Hayashi Y., Kage E., Hirotsu T., Takeushi H., Kunitomo H., Iino Y. and Kubo T.

Neuroscience Research, 50, S168-S168