HIROTSU BIO SCIENCE INC. (Head Office: Chiyoda-ku, Tokyo; Representative; Takaaki Hirotsu (Hereinafter referred to as “HIROTSU”)), is pleased to announce that the test kit shipments for the canine cancer test “N-NOSE plus Dogs” will begin on Tuesday, May 9, and we will provide the “Owner and Dog Pair Test.”

The cancer incidence rate in dogs is said to be eight times higher than in humans, and cancer is the leading cause of death among dogs (*1). Since dogs cannot report pain or discomfort themselves, it is often the case that the illness has progressed by the time the owner notices something is wrong. In a landscape where convenient cancer screenings for dogs are almost non-existent, we have fully committed to developing a nematode-based cancer test for dogs, driven by our desire to protect canine health. After approximately five years of joint research with partner institutions, we are now ready to offer this service (*2).
“N-NOSE plus Dogs” is a primary screening test for assessing cancer risk in dogs, developed by applying the technology of the nematode cancer test “N-NOSE,” which has surpassed a cumulative total of 400,000 users (*3). By simply submitting a urine sample, owners can check for risks of various cancers commonly found in dogs, such as lymphoma, mammary gland cancer, and skin cancer (*4). Following a reservation period starting on March 10, we will now begin shipping test kits and conducting tests. Additionally, we will offer the service of the “Owner and Dog Pair Test” to ensure a healthy future for both owners and their dogs, providing a cost-effective option. Should the test indicate a high risk, we will provide free aftercare services, including guidance from veterinarians on the next steps and information about partner animal hospitals, to support a process that leads to early detection.
Overview of “N-NOSE plus Dogs”

Start Date: Tuesday, May 9, 2023
How to Apply for Service: Service website, and partner animal hospitals (starting from early June)
Test Fee:
Regular Testing: ¥16,800 (including tax) per test (choose from once a year, twice a year, or three times a year)
One-Time Test: ¥19,800 (including tax)
“Owner and Dog Pair Test” Discount (applicable for up to 5 family members of the owner and up to 5 dogs):
Regular Testing: ¥2,000 discount per kit
One-Time Test: ¥1,000 discount per kit
Service Website: https://lp.n-nose.com/dog/
(*1) Dog cancer incidence rate: Calculated from the figures in “Anicom Household Pet White Paper 2022” for dogs over 6 years old, cancer incidence rates in people over 40 from “National Cancer Registry” 2019 data and “Ministry of Health, Labour and Welfare Vital Statistics” 2019 data. Dog mortality data: “Anicom Household Pet White Paper 2021” for dogs over 10 years old.
(*2) Results of Collaborative Research:
[Paper]
December 2022: “A new detection method for canine and feline cancer using the olfactory system of nematodes” (Biochemistry and Biophysics Reports)
[Conference Presentations]
(*3) As of the end of April 2023
(*4) Liver cancer, mammary gland cancer, lymphoma, thyroid cancer, multiple myeloma, sarcoma, bone tumor, urothelial cancer, brain tumor
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