Achievements

ACADEMIC PAPERS

2019

Application of C. elegans cancer screening test for the detection of pancreatic tumor in genetically engineered mice.

Yuji Ueda, Koichi Kawamoto, Masamitsu Konno, Kozo Noguchi, Satoru Kaifuchi, Taroh Satoh, Hidetoshi Eguchi, Yuichiro Doki, Takaaki Hirotsu, Masaki Mori and *Hideshi Ishii

Oncotarget. 2019; 10:5412-5418.(peer-reviewed)

2015

A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection

*Hirotsu T., Sonoda H., Uozumi T., Shinden Y., Mimori K., Maehara Y., Ueda N., Hamakawa M.

PLOS ONE, 10(3): e0118699(peer-reviewed)

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Hamakawa M., Deno Y., Nakajo M., *Hirotsu T.

Genes to Cells, 20, 802-816(peer-reviewed)

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.

Hamakawa M., Uozumi T., Ueda N., Iino Y, *Hirotsu T.

BMC Biology, 13:6(peer-reviewed)

Cancer screening test using C. elegans scent detection.

*Hirotsu T.

Aroma Research, 16, 134-136(invitation)

2014

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.

Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., *Hirotsu T.

Science Signaling, 7 (323), ra39(peer-reviewed)

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.

*Hirotsu T.

Aroma Research, 15, 242-243(invitation)

2013

In vivo imaging of Ras protein’s activity in olfactory neurons.

Uozumi T., Yamada R., Suzuki A., Taniguchi G., Yoshida K., Iino Y., Ishihara T., *Hirotsu T.

Protocol Exchange, 2013, 011(invitation)

2012

Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.

Uozumi T., *Hirotsu T., Yoshida K., Yamada R., Suzuki A., Taniguchi G., Iino Y., and Ishihara T.

(Nature) Scientific Reports, 2, 500(peer-reviewed)

Odour concentration-dependent olfactory preference change in C. elegans.

Yoshida K., *Hirotsu T., Tagawa T., Oda S., Wakabayashi T., Iino Y., and Ishihara T.

Nature Communications, 3, 739(peer-reviewed)

Live imaging of signaling protein’s activity responding to odorant stimuli.

Uozumi T., *Hirotsu T

Aroma Research, 13, 244(invitation)

Neural mechanisms of olfactory preference change depending on the odor concentration.

Yoshida K., *Hirotsu T.

Aroma Research, 13, 137(invitation)

Scent aroma derived from woods: the consideration based on the physiological and psychological effects.

Shimizu K., Hirotsu T. (8th author) et al.

Aroma Research, 13, 202-208(invitation)

Comprehensive analysis of olfactory receptors in C. elegans

*Hirotsu T., Taniguchi G., Kiriyama K., Kamizaki T., Sato N. and Ishihara T.

Genetics in 21th Century, VIII, 12(invitation)

2011

Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans.

Shinkai Y., Yamamoto Y., Fujiwara M., Tabata T., Murayama T., Hirotsu T., Ikeda D., Tsunozaki M., Iino Y., Bargmann C., Katsura I., and Ishihara T.

Journal of Neuroscience, 31, 3007-3015

2010

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.

Yamada K., Hirotsu T., Matsuki M., Butcher A., Tomioka M., Ishihara T., Clardy J., Kunitomo H. and Iino Y.

Science, 329, 1647-1650(peer-reviewed)

2009

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.

Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H., Ishihara T., Iino Y. and Kubo T.

Nature Neuroscience, 12, 981-987(peer-reviewed)

Behavioural assay for olfactory plasticity in C. elegans.

Hirotsu T., Hayashi Y., Iwata R., Kunitomo H., Kage-Nakadai E., Kubo T., Ishihara T. and Iino Y.

Nature Protocols, 2009, 139(invitation)

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.

Yamada K., Hirotsu T., Matsuki M., Kunitomo H. and Iino Y.

Genetics, 181, 1347-1357(peer-reviewed)

2008

Analysis of neural mechanisms of behavioral changes depending on odor concentrations.

Yoshida K., *Hirotsu T., Ishihara T. and Iino Y.

Genetics in 21th Century, V, 5(invitation)

2005

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.

Hirotsu T. and Iino Y.

Genes to Cells, 10, 517-530(peer-reviewed)

MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive neurites in Caenorhabditis elegans.

Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.

Current Biology, 15, 1554-1559(peer-reviewed)

2000

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.

Hirotsu T., Saeki S., Yamamoto M. and Iino Y.

Nature, 404, 289-93(peer-reviewed)

1999

Novel functions of the Ras-MAPK signal transduction pathway in neurons of C. elegans.

Hirotsu T., Saeki S. and Iino Y.

Worm Breeder's Gazette,15, 41

Proceedings papers

2014

The neural circuit mechanisms in the olfactory preference change after odor experience

Ueda N, Matsuo T, *Hirotsu T.

GENES & GENETIC SYSTEMS, 89, 335-335

2012

The Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M, Iino Y, *Hirotsu T.

GENES & GENETIC SYSTEMS, 87, 405-405

Systematic identification of the relationship between olfactory receptors and odorants in C. elegans

Taniguchi G, Kriyama K, Kamizaki T. *Hirotsu T.

GENES & GENETIC SYSTEMS, 87, 407-407

Identification of neural circuits of central olfactory adaptation in C. elegans

Matsuo T, *Hirotsu T

GENES & GENETIC SYSTEMS, 87, 408-408

2011

Best Paper award3D-03 Systematic identification of specific receptors for odorants in C. elegans

*Hirotsu T., Taniguchi G., Kiriyama K., Kamizaki T., Noriko Sato and Ishihara T.

GENES & GENETIC SYSTEMS, 86, 437-437

In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behaviour

Uozumi T., *Hirotsu T., et al.

Neuroscience Research, 71, E79-E79

Coordinated change of acting sensory neurons is important for olfactory preference change depending upon odor concentration

Yoshida K., *Hirotsu T., et al.

Neuroscience Research, 71, E174-E174

2009

Live imaging of Ras activity in olfactory neurons in C. elegans.

*Hirotsu T., Yamada R., Suzuki A. and Ishihara T.

Neuroscience Research, 65, S175-S175

Analysis of putative olfactory receptor genes in C. elegans.

Kiriyama K., *Hirotsu T., Kamizaki T., Noriko Sato and Ishihara T.

Neuroscience Research, 65, S175-S175

2008

Best Paper awardAnalysis of a neural circuit for the aversive response to high concentration of an attractive odorant in C. elegans.

Yoshida K., *Hirotsu T., Iino Y and Ishihara T.

GENES & GENETIC SYSTEMS, 83, 490-490

The neprilysin gene nep-2 is involved in olfactory adaptation in C. elegans.

Yamada K. Hirotsu T., Matsuki M. Kunitomo H. and Iino Y.

GENES & GENETIC SYSTEMS, 83, 490-490

G protein signaling in olfactory systems of C. elegans.

*Hirotsu T., Yamada R., Kamizaki T., Noriko Sato and Ishihara T.

Neuroscience Research, 61, S105-S105

2007

The neprilysin gene nep-2 is involved in olfactory adaptation in C. elegans.

Yamada K. Hirotsu T., Matsuki M. Kunitomo H. and Iino Y.

Neuroscience Research, 58, S216-S216

2006

Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans.

Hirotsu T. Ishihara T. Nishida E. and Iino Y.

Neuroscience Research, 55, S251-S251

Analysis of the significance and mechanism of neurite elimination using C. elegans as a model.

Hayashi Y., Hirotsu T., Kage E., Takeushi H., Kunitomo H., Iino Y. and Kubo T.

Neuroscience Research, 55, S185-S185

2004

A novel C. elegans transcription factor MBR-1 is involved in olfactory plasticity and axon pruning.

Hayashi Y., Kage E., Hirotsu T., Takeushi H., Kunitomo H., Iino Y. and Kubo T.

Zoological Science, 21, 1318-1318

The Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans.

Hirotsu T. and Iino Y.

Neuroscience Research, 50, S66-S66

Analysis of the function of MBR-1, a C. elegans transcription factor incolved in olfactory plasticity , in axon pruning.

Hayashi Y., Kage E., Hirotsu T., Takeushi H., Kunitomo H., Iino Y. and Kubo T.

Neuroscience Research, 50, S168-S168