Achievements

CONFERENCE PRESENTATIONS

2019
Jul.

Oral presentationVerification of cancer screening using N-NOSE

*Enomoto M., Inaba S., Yabuki H., Inoue M., Ooe N., Shimozono N., Nobutoki T., Ono N., Uozumi T., Hirotsu T.

The 60th Annual Scentific Meeting of Japana Society of Ningen Dock

Jul.

Invited"Special lecture 3" Invention and practical realization of novel cancer screening test N-NOSE

Takaaki Hirotsu

The 60th Annual Scentific Meeting of Japana Society of Ningen Dock

Jun.

General lectureInvention and practical application for cancer-detecting test, N-NOSE

Naoki Shimozono

The 19th Scientific Meeting of the Japanese Society of Anti-Aging Medicine

Jun.

General lecture"Symposium 2" Evolving the disease-specific biomarker included in urine

Takayuki Uozumi

Japanese Society of Veterinary Clinical Pathology 2019

Jun.

Poster presentationCancer screening test using the chemotaxis behavior of C. elegans

Toshimi Sugimoto

26th Japanese Association for Cancer Prevention

May

InvitedInvention and practical application for cancer-detecting test, N-NOSE

Takaaki Hirotsu

68th JAMT CONGRESS 2019 SHIMONOSEKI

May

Oral presentationLatest research and development of cancer screening test N-NOSE

Takayuki Uozumi

1st Japanese Society for Biological Diagnosis

May

General lectureBiosensor:Nematodes

Takaaki Hirotsu

1st Japanese Society for Biological Diagnosis

Apr.

InvitedInvention and practical application for cancer-detecting test, N-NOSE

Takaaki Hirotsu

81th JAPANESE SOCIETY OF ENZYME ENGINEERING

Oral presentationIntarnationalN-NOSE: 1st screening technology for cancer using nematode olfaction

Matsunaga Y.

6th Annual US Japan Workshop on Cancer Biomarkers

2018
Oct.

Oral presentationNematode-NOSE (N-NOSE) enables to detect early-stage cancer acculately

*Niihara T., Yoshinaga T., Uozumi T., Nio T., Hirotsu T., et al.

36th Meeting of the Japan Society of Colon Examination

2017
Nov.

InvitedIntarnationalN-NOSE: Cancer screening from early phase with a drop of urine using C. elegans

Takaaki Hirotsu

Brisbane Cancer Conference 2017

Sep.

InvitedInvention and practical application for cancer-detecting test, N-NOSE

Takaaki Hirotsu

Japan Society for Medical Application of Stable Isotope and Biogas

Sep.

InvitedInvention and practical application for cancer-detecting test, N-NOSE

Takaaki Hirotsu

Japanese society for disease of the colon and rectum in Saitama

Sep.

InvitedInvention and practical application for cancer-detecting test, N-NOSE

Takaaki Hirotsu

Biochemical Assay Society of Japan

2016
Nov.

InvitedDetecting early-cancer using C. elegans

*Takaaki Hirotsu

Japan Gastroenterological Endoscopy Society

Oct.

InvitedPractical application for cancer-detecting test, N-NOSE

*Takaaki Hirotsu

JAMT Congress, Kanto-Koshinetsu 

Oct.

InvitedFuture of cancer screening test using olfaction of living

*Takaaki Hirotsu

Aroma Science Forum

Sep.

InvitedDevelopment of cancer diagnose system using olfaction of C. elegans

*Takaaki Hirotsu

14th Medical Device Forum

Jul.

InvitedDetecting early-cancer using one drop of urine by C. elegans

*Takaaki Hirotsu

「Innovation of Amazing livings」Japan Bioindustry Association

May

InvitedInvention and Future for cancer-detecting test, N-NOSE

Takaaki Hirotsu

Japan Society of Clinical Proteome

Mar.

InvitedA highly accurate cancer diagnosis system using nematode scent detection (n-nose)

*Takaaki Hirotsu

AMED-NIH cancer workshop

Jan.

InvitedCancer diagnosis using C. elegans

*Takaaki Hirotsu

18th UTP Symposium

2015
Nov.

Utilization of C. elegans olfaction as comprehensive and accurate cancer screening test

Sonoda H., Hirotsu T. (2nd author among 7 authors), et al.

JAPANESE CANCER ASSOCIATION

Oct.

Comprehensive and accurate cancer screening test using C. elegans olfaction

Sonoda H., Hirotsu T. (2nd author among 16 authors), et al.

Japan Sciety of Clinical Oncology

Aug.

InvitedOlfaction of C. elegans and its possibility

*Takaaki Hirotsu

Society of Evolutionary Studies, Japan

Jul.

InvitedDevelopment of cancer detecting using olfaction of C. elegans

*Takaaki Hirotsu

OPACK(Kyushu University)

Jul.

Oral presentationIntarnationalA novel method for Time- and Cell-specific RNAi reveals the temporal role of Ras in the motor neurons controlling exploratory behavior

Hamakawa M., Uozumi T., Ueda N., Iino Y., *Hirotsu T.

Neuro2015

Jul.

Oral presentationIntarnationalThe analysis of the neuropeptide signaling in the neural circuit-dependent odor adaptation

Ueda N, Matsuo T, *Hirotsu T

Neuro2015

Jun.

Oral presentationIntarnationalA novel method for time- and cell-specific RNAi revealed the profile of Let-60Ras in exploratory behavior

Hamakawa M., Uozumi T., Ueda N., Iino Y., *Hirotsu T.

International C. elegans meeting

2014
Dec.

InvitedIntarnationalA highly accurate cancer diagnosis system using C. elegans scent detection

*Hirotsu T, Sonoda H, Uozumi T, Mimori K, Maehara Y, Hamakawa M

12th ISMNTOP

Dec.

IntarnationalSwitching of olfactory receptors depending on odor concentrations in C. elegans

Taniguchi G, Hamakawa M, Uozumi T, Kiriyama K, Kamizaki T, *Hirotsu T

12th ISMNTOP

Dec.

IntarnationalThe neural circuit mechanisms regulating olfactory preference change (olfactory central adaptation) after odor experience in C. elegans

Ueda N, Matsuo T, *Hirotsu T

12th ISMNTOP

Dec.

Voltage-dependent anion channel (VDAC-1) plays a role in olfactory signal pathway in C. elegans

Uozumi T., Ideno Y., *Hirotsu T.

The Molecular Biology Society of Japan

Nov.

Voltage-dependent anion channel (VDAC-1) is essential for olfactory signal transduction in C. elegans

Uozumi T., Ideno Y.,*Hirotsu T.

The Japanese Association for the Study of Taste and Smell

Nov.

Separately activation of types of olfactory receptors depending on the odor concentration

Taniguchi G., Hamakawa M., Uozumi T., Kiriyama K., Kamizaki T.,*Hirotsu T.

The Japanese Association for the Study of Taste and Smell

Sep.

Analysis of neural circuit regulating experience-based preference alteration

Ueda N., Matsuo T., *Hirotsu T.

The Japan Genetics society

Jul.

Oral presentationIntarnationalA novel method, time- and cell-specific RNAi, revealed the function of Ras in neurons regulating exploratory behavior oral presentation

Hamakawa M., Uozumi T., Ueda N., Iino Y., *Hirotsu T.

Neuro2014

Jun.

IntarnationalAnalysis of functions of LET-60Ras in regulation of exploratory behavior by a novel method, time- and cell-specific RNAi.

Hamakawa M., Uozumi T., Ueda N., Iino Y., *Hirotsu T.

The 6th Asia-pacific C. elegans Meeting

2013
Dec.

Ras-MAPK pathway is essential to regulate the glutamte receptor localization for foraging behavior in C. elegans

Hamakawa M., Iino Y., *Hirotsu T.

The Molecular Biology Society of Japan

Dec.

Invsetigation of olfactory adaptation regulated by the central neural corcuit in C. elegans

Matsuo T., *Hirotsu T.

The Molecular Biology Society of Japan

Dec.

Analysis of physiological effects caused by odor in C. elegans

Matsuo T., Shimizu K., Okamoto T., *Hirotsu T.

The Molecular Biology Society of Japan

Nov.

InvitedIntarnationalThe Ras-MAPK pathway plays multiple roles in the olfactory systems of C. elegans.

*Hirotsu T.

World Gene Convention

Jun.

Oral presentationIntarnationalScreening of odor-receptor pairs reveals concentration-dependent switches in olfactory receptors

Uozumi T., Taniguci G., Kiriyama K., Kamizaki T., *Hirotsu T.

Neuro2013

Jun.

IntarnationalThe Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M. Iino Y., *Hirotsu T.

Neuro2013

Apr.

InvitedIntarnationalThe Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.

*Hirotsu T.

World DNA and Genome Day

2012
Dec.

Oral presentationOdorant-receptor interactions revealed by comprehensive RNAi screening in C. elegans

Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., Sato N., *Hirotsu T.

The Molecular Biology Society of Japan

Dec.

Investigation of the central nervous system regulating the olfactory adaptation in C. elegans

Matsuo T., *Hirotsu T.

The Molecular Biology Society of Japan

Dec.

Ras-MAPK pathway had a role in foraging behavior of C. elegans

Hamakawa M., Iino Y., 、*Hirotsu T.

The Molecular Biology Society of Japan

Dec.

In-vivo imaging revealed the quick alteration of Ras activity had a role in olfaction

Uozumi T., *Hirotsu T., Yoshida K., Yamada R., Suzuki A., Iino Y., Ishihara K.

The Molecular Biology Society of Japan

Sep.

Oral presentationIntarnationalIn vivo Imaging Reveals Regulatory Mechanisms and Functions of Ras Activity in Olfactory Neurons

Uozumi T., *Hirotsu T., et al.

Neuroscience2012

Sep.

Oral presentationAnalysis of central neural circuit regulating olfactory adaptation by C. elegans

Matsuo T., *Hirotsu T.

The Japan Genetics society

Sep.

Oral presentationThe function of Ras-MAPK pathway for foraging behavior in C. elegans

Hamakawa M., Iino Y., *Hirotsu T.

The Japan Genetics society

Sep.

Oral presentationComprehensive RNAi screening to reveal the odorant-receeptor interactions in C. elegans

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., *Hirotsu T.

The Japan Genetics society

Jun.

IntarnationalNeuronal mechanisms underlying olfactory preference change depending upon odor concentration

Yoshida K., *Hirotsu T., et al.

ISOT(International Symposium on Olfaction and Taste)

Jun.

Oral presentationIntarnationalSystematic identification of olfactory receptors for odorants

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., *Hirotsu T.

East Asia Worm Meeting

Jun.

Oral presentationIntarnationalIn vivo Imaging of Ras Activity in Olfactory Neurons Suggests its Transient Activation is Important for Olfactory Behavior

Uozumi T., *Hirotsu T., et al.

East Asia Worm Meeting

2011
Dec.

Oral presentationIn vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Uozumi T., *Hirotsu T., et al.

The Molecular Biology Society of Japan

Dec.

Oral presentationSystematic identification of olfactory receptor for odorants in C. elegans

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Ishihara K., *Hirotsu T.

The Molecular Biology Society of Japan

Sep.

Oral presentationIntarnationalIn vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Uozumi T., *Hirotsu T., et al.

Neuroscience2011

Sep.

IntarnationalCoordinated change of acting sensory neurons is important for olfactory preference change depending upon odor concentration

Yoshida K., *Hirotsu T., et al.

Neuroscience2011

Jun.

Oral presentationIn vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

*Hirotsu T., et al.

Japan Society for Cell Biology

Jun.

IntarnationalOlfactory preference switch depending on odor concentration is mediated by combinatorial change of acting sensory neurons

Yoshida K., *Hirotsu T., et al.

International Worm Meeting

2010
Dec.

Live imaging of Ras activation in C. elegans olfactory neurons

Uozumi T.,*Hirotsu T., et al.

BMB2010

Dec.

Comprehensive screening of olfactory receptors in C. elegans

*Hirotsu T., et al.

BMB2010

Aug.

InvitedLive imaging of the activation of Ras in olfactroy neurons of C. elegans

*Hirotsu T., et al.

Imaging WorkShop

Jul.

IntarnationalNeural and Behavioral Mechanisms of Response to an Odorant Depending on its Concentration.

Yoshida K., *Hirotsu T., et al.

East Asia C. elegans Meeting

Jul.

InvitedIntarnationalAscaroside Pheromones Regulate Olfactory Plasticity through the SNET-1 Peptide.

Yamada K., Hirotsu T., et al.

East Asia C. elegans Meeting

Jul.

Oral presentationIntarnationalLive imaging of Ras activity in olfactory systems in C. elegans.

Uozumi T., *Hirotsu T., et al.

C. elegans Neuro

Jul.

IntarnationalNeural and Behavioral Mechanisms of Response to an Odorant Depending on its Concentration.

Yoshida K., *Hirotsu T., et al.

C. elegans Neuro

Jul.

Oral presentationIntarnationalAscaroside Pheromones Regulate Olfactory Plasticity through the SNET-1 Peptide.

Yamada K., Hirotsu T., et al.

C. elegans Neuro

2009
Nov.

Oral presentationIntarnationalLive imaging of Ras activity in olfactory neurons in C. elegans.

*Hirotsu T., et al.

International Symposium on Cellular Signaling

Jun.

Oral presentationIntarnationalOlfactory adaptation is regulated by a peptide signal in C. elegans.

Yamada K., Hirotsu T., et al.

International C. elegans Meeting

Jun.

IntarnationalSystematic identification of specific receptors for odorants in C. elegans

Kiriyama K., *Hirotsu T., et al.

International C. elegans Meeting

Jun.

IntarnationalLive imaging of Ras activity in olfactory neurons in C. elegans.

*Hirotsu T., et al.

International C. elegans Meeting

2008
Dec.

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.

Maeda K., *Hirotsu T., et al.

BMB2008

2007
Dec.

Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans

Hirotsu T., et al.

BMB2007

Dec.

Mechanisms of neural circuit-dependent olfactory adaptation of C. elegans

平江彰伍、*Hirotsu T., et al.

BMB2007

Jun.

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans

*Hirotsu T., et al.

Neuro2007

2006
Nov.

IntarnationalGLR-1 glutamate receptor is regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation.

Hirotsu T., et al.

East Asia C. elegans Meeting

Jun.

IntarnationalGlutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans

Hirotsu T., et al.

Neuro2006

2005
Dec.

Oral presentationMechanisms of neural circuit-dependent olfactory adaptation of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Oct.

Oral presentationMechanisms of olfactory plasticity of C. elegans: Regulation of localization of glutamate receptors

Hirotsu T., et al.

The Japan Genetics society

Nov.

IntarnationalThe Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans

Hirotsu T., et al.

International C. elegans Meeting

2004
Jun.

Oral presentationThe Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans

Hirotsu T., et al.

Neuro2004

2003
Dec.

Oral presentationMechanisms of olfactory plasticity of C. elegans: Regulation of localization of glutamate receptors

Hirotsu T., et al.

The Molecular Biology Society of Japan

Oct.

Oral presentationMechanisms of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Genetics society

2002
Dec.

Multiple roles of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Jul.

Oral presentationThe Ras-MAPK signal transduction pathway is important for olfactory plasticity.

Hirotsu T., et al.

Japanese Worm Meeting

Jul.

IntarnationalThe Ras-MAPK pathway acts in interneurons for olfactory plasticity.

Hirotsu T., et al.

West Coast Worm Meeting

2001
Dec.

Multiple roles of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

2000
Dec.

IntarnationalTHE RAS ⁄ MAP KINASE PATHWAY IS INVOLVED IN OLFACTION IN CAENORHABDITIS ELEGANS

Hirotsu T., et al.

Annual Meeting of Society for Neuroscience

Dec.

Oral presentationInvolvement of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Aug.

Oral presentationThe Ras-MAPK signal transduction pathway plays multiple roles in chemotaxis to odorants

Hirotsu T., et al.

Japanese Worm Meeting

Jun.

IntarnationalMultiple roles for the Ras-MAPK signal transduction pathway in chemotaxis to odorants?

Hirotsu T., et al.

West Coast Worm Meeting

Jun.

Involvement of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Neuroscience Society

1999
Dec.

Functions of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Jul.

IntarnationalNovel functions of the Ras-MAPK signal in neurons of C. elegans

Hirotsu T., et al.

International C. elegans meeting

1998
Dec.

Involvement of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan