研究実績

-ORIGINAL PAPERS- 論文

Novel functions of the Ras-MAPK signal transduction pathway in neurons of C. elegans.
Hirotsu T., Saeki S. and Iino Y.
Worm Breeder’s Gazette,15, 41 (1999)

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.
Hirotsu T., Saeki S., Yamamoto M. and Iino Y.
Nature,
404, 289-93 (2000)

MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive
neurites in Caenorhabditis elegans.
Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.
Current Biology, 15, 1554-1559 (2005)

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.
Hirotsu T. and Iino Y.
Genes to Cells, 10, 517-530 (2005)

Analysis of neural mechanisms of behavioral changes depending on odor
concentrations Yoshida K., *Hirotsu T., Ishihara T. and Iino Y. * Corresponding author
Genetics in 21th Century, V, 5 (2008)

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.
Yamada K., Hirotsu T., Matsuki M., Kunitomo H. and Iino Y.
Genetics, 181, 1347-1357 (2009)

Behavioural assay for olfactory plasticity in C. elegans.
Hirotsu T., Hayashi Y., Iwata R., Kunitomo H., Kage-Nakadai E., Kubo T., Ishihara T. and Iino Y.
Nature Protocols, 2009, 139 (2009)

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H., Ishihara T., Iino Y. and Kubo T.
Nature Neuroscience, 12, 981-987 (2009)

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
Yamada K., Hirotsu T., Matsuki M., Butcher A., Tomioka M., Ishihara T., Clardy J., Kunitomo H. and Iino Y.
Science, 329, 1647-1650 (2010)

Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans.
Shinkai Y., Yamamoto Y., Fujiwara M., Tabata T., Murayama T., Hirotsu T., Ikeda D., Tsunozaki M.,
Iino Y., Bargmann C., Katsura I., and Ishihara T.
Journal of Neuroscience, 31, 3007-3015 (2011)

Scent aroma derived from woods: the consideration based on the physiological and psychological effects.
Shimizu K., Hirotsu T. et al.
Aroma Research, 13, 202-208 (2012)

Live imaging of signaling protein’s activity responding to odorant stimuli.
Uozumi T., *Hirotsu T.
* Corresponding author
Aroma Research, 13, 244 (2012)

Odour concentration-dependent olfactory preference change in C. elegans.
Yoshida K., *Hirotsu T., Tagawa T., Oda S., Wakabayashi T., Iino Y., and Ishihara T.
* Corresponding author
Nature Communications, 3, 739 (2012)

Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.
1Uozumi T., 1*Hirotsu T., Yoshida K., Yamada R., Suzuki A., Taniguchi G., Iino Y., and Ishihara T.
1 equally contributed
* Corresponding author
(Nature) Scientific Reports, 2, 500 (2012)

Comprehensive analysis of olfactory receptors in C. elegans
*Hirotsu T., Taniguchi G., Kiriyama K., Kamizaki T., Sato N. and Ishihara T.
* Corresponding author
Genetics in 21th Century, VIII, 12 (2012)

In vivo imaging of Ras protein’s activity in olfactory neurons.
Uozumi T., Yamada R., Suzuki A., Taniguchi G., Yoshida K., Iino Y., Ishihara T., *Hirotsu T.
* Corresponding author
Protocol Exc hange, 2013, 011 (2013)

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.
*Hirotsu T. * Corresponding author
Aroma Research, 15, 242-243 (2014)

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.
Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., *Hirotsu T.
* Corresponding author
Science Signaling, 7 (323), ra39 (2014)

Cancer screening test using C. elegans scent detection.
*Hirotsu T.  
* Corresponding author
Aroma Research, 16, 134-136 (2015)

A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection
*Hirotsu T., Sonoda H., Uozumi T., Shinden Y., Mimori K., Maehara Y., Ueda N., Hamakawa M.
* Corresponding author
PLOS ONE, 10(3): e0118699 (2015)

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.
Hamakawa M., Uozumi T., Ueda N., Iino Y, *Hirotsu T.
* Corresponding author
BMC Biology, 13:6 (2015)

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans
Uozumi T., Hamakawa M., Deno Y., Nakajo M., *Hirotsu T.
* Corresponding author
Genes to Cells, 20, 802-816 (2015)

-REVIEWS- 総説・著書

The Ras-MAPK signal transduction pathway plays multiple roles in chemotaxis to odorants
Iino Y., Hirotsu T
Experimental Medicine 18, 2314-2319 (2000)

Olfactory receptor and Ras/MAP Kinase
Hirotsu T.
Clinical Neuroscience 31, 669-672 (2013)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Human-Health-Future 7, 30-37 (2015)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Gakushikai 914, 82-85 (2015)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
B & I 73, 487-488 (2015)

Bio-sensor -Cancer diagnosis using olfaction of C. elegans-
Hirotsu T.
Journal of Japan Association on Odor Environment 46, 191-199 (2015)

Odour concentration-dependent olfactory preference change in C. elegans.
Hirotsu T.
Journal of Japan Association on Odor Environment 47, 2-9 (2016)

Advantage of Cancer diagnosis using C. elegans
Hirotsu T.
Japan Medical Journal 4791, 63-64 (2016)

Smell and Me
Hirotsu T.
Journal of Japan Association on Odor Environment 47, 44 (2016)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
BIO INDUSTORY 33, 5, 3-10 (2016)

Cancer diagnosis using C. elegans
Hirotsu T.
「Science of Living」 67, 178-183  (2016)

High accurate cancer-detecting method using C. elegans olfaction method
Hirotsu T.
“Bio-measuring supports health care” CMC 112-120 (2016)

Technical development for new cancer diagnosis using C. elegans
Hirotsu T.
“Hematology Frontier” Medical and Drug Journal, Co., ltd. 26, 1423-1429 (2016)

A new method for time and cell-specific RNAi
Hamakawa M., Hirotsu T.
Methods in Molecular Biology, 1507(67-79) (2016)

Technical development for cancer diagnosis using a slight amount of urine
Hirotsu T.
“R&D of future treatment and diagnosis technique of cancer” Technical Information Institute Co., Ltd. Section 6 (2016)

Diagnostic of cancer by smell substances
Hirotsu T.
“Olfaction  new horizon “ Clinical Neuroscience (2016)

Possibility of early diagnostic of cancer using olfaction of C. elegans
Hirotsu T.
Pharma Medica 34, 33-38(2016)

Cancer screening system using olfaction of C. elegans
Uozumi T., Hirotsu T.
“Next-generation research of cancer” NTS Section 4-2(2017)

Tell us about love for C. elegans.
Hirotsu T.
The Society for Bioscience and Bioengineering 6, 345-347(2017)

Diagnostic skills and sensitivity improvement using urine
Kaifuchi F., Hirotsu T.
“Early diagnosis of diseases” Technical Information Institute Co., Ltd. Section 5(2017)

Development of highly accurate cancer screening test using C. elegans
Uozumi T., Hirotsu T.
“New development of medical care of cancer” CMC Section 2-5(2017)

Cancer diagnosis by odorants Hirotsu T.
“Diseases of sensory organs” Japan Medical Association Section 6(2018)

-INVITED LECTURES- 招待講演

The Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.
Hirotsu T.
World DNA and Genome Day(April, 2013)

The Ras-MAPK pathway plays multiple roles in the olfactory systems of C. elegans.
Hirotsu T.
World Gene Convention(Nov, 2013)

A highly accurate cancer diagnosis system using C. elegans scent detection
Hirotsu T., Sonoda H, Uozumi T, Mimori K, Maehara Y, Hamakawa M
12th ISMNTOP(Dec, 2014)

Cancer detecting using olfaction of C. elegans and the future of biosensor
Hirotsu T.
Kurume Research Park(May, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Aflac Fukuoka (July, 2015)

Cancer detecting by C. elegans
Hirotsu T.
Aflac Osaka (July, 2015)

Development of cancer detecting using olfaction of C. elegans
Hirotsu T.
OPACK(Kyushu University) (July, 2015)

Cancer detecting by C. elegans
Hirotsu T.
Kyushu Environmental Evaluation Association(Aug, 2015)

Talking about C. elegans and its experiment
Hirotsu T.
Mamoroom Fukuoka(Aug, 2015)

Olfaction of C. elegans and its possibility
Hirotsu T.
Society of Evolutionary Studies, Japan(Aug, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Nikkei Digital Health (Sep, 2015)

Diagnose cancer using only one drop of urine!
Hirotsu T.
Club Kansai(Sep, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Japan Health Foundation (Sep, 2015)

Cancer screening test using C. elegans
Hirotsu T.
Houken Kansai Corp.(Nov, 2015)

Cancer screening test using C. elegans and my career development
Hirotsu T.
Yamaguchi University(Nov, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Kyushu University(Nov, 2015)

Invention and Future for cancer-detecting test, N-NOSE
Hirotsu T.
Kanagawa R&D Promotion Council(Dec, 2015)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Farmers(Dec, 2015)

Cancer diagnosis using C. elegans
Hirotsu T.
18th UTP Symposium(Jan, 2016)

Doctor of C. elegans. Diagnose using only one drop of urine!
Hirotsu T.
Kyushu University Reunion in Kansai Area(Jan, 2016)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Aflac Fukuoka(Feb, 2016)

Doctor of C. elegans.
Hirotsu T.
Itoshima Science Caravan(Feb, 2016)

Doctor of C. elegans. Diagnose cancer using only one drop of urine!
Hirotsu T.
Tagawa Shinkin Group(Feb, 2016)

Invention and Future for cancer-detecting test, N-NOSE
Hirotsu T.
AGC Asahi Glass(Mar, 2016)

A highly accurate cancer diagnosis system using nematode scent detection (n-nose)
Hirotsu T.
AMED-NIH cancer workshop(Mar, 2016)

Invention and Future for cancer-detecting test, N-NOSE
Hirotsu T.
Japan Society of Clinical Proteome(May, 2016)

Diagnosis of Early cancer using olfaction of C. elegans
Hirotsu T.
Kumamoto University(May, 2016)

Detecting early-cancer using one drop of urine by C. elegans
Hirotsu T.
「Innovation of Amazing livings」Japan Bioindustry Association(July, 2016)

Detecting early-cancer using one drop of urine by C. elegans
Hirotsu T.
Aflac(Sep, 2016)

Development of cancer diagnose system using olfaction of C. elegans
Hirotsu T.
14th Medical Device Forum(Sep, 2016)

Future of the method of cancer screening test using C. elegans
Hirotsu T.
Aflac(Oct, 2016)

Future of cancer screening test using olfaction of living
Hirotsu T.
Aroma Science Forum(Oct, 2016)

Practical application for cancer-detecting test, N-NOSE
Hirotsu T.
JAMT Congress, Kanto-Koshinetsu (Oct, 2016

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
Kumamoto University(Oct, 2016)

Cancer screening test using C. elegans
Hirotsu T.
Houken Corp.(Oct, and Nov, 2016)

Detecting early-cancer using C. elegans
Hirotsu T.
Japan Gastroenterological Endoscopy Society(Nov, 2016)

Cancer at present and future
Hirotsu T.
Douyukai Representative Steering Committee(Dec, 2016)

Lecture and Experiment for C. elegans
Hirotsu T.
Mamoroom Fukuoka(Jan, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Kita-Kyushu Chamber of Commerce and Industry(Aug, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T
Aflac(Mar, 2017)

Cancer screening test using C. elegans
Hirotsu T.
Houken Kansai Corp.(May, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Metlife (May, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Biochemical Assay Society of Japan(June, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Aflac, Osaka(July, 2017)

Aiming for practical application of N-NOSE
Hirotsu T.
Osaka Kosei Shinyo Kinko(July, 2017)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
Tosu Miyaki Medical Association(Aug, 2017)

Venture start-up and corporate activities aiming for practical application of N-NOSE
Hirotsu T.
Kita-Kyushu Chamber of Commerce and Industry(Aug, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Japan University Health Association in Kyushu Area(Aug, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Tokushima Young Investigators Conference(Sep, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Japanese society for disease of the colon and rectum in Saitama(Sep, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Japan Society for Medical Application of Stable Isotope and Biogas(Sep, 2017)

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
The Hitachi Global Foundation(Oct, 2017)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
The Tokio Marine Life Insurance Co., Ltd. (Oct, 2017)

R&D of Cancer screening test using C. elegans
Hirotsu T.
Houken Corp.(Oct, 2017)

R&D of Cancer screening test using C. elegans
Hirotsu T.
Houken Chubu Corp.(Nov, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Aflac Osaka(Nov, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Kyoto Independent Insurance Agent Association(Nov, 2017)

N-NOSE: Cancer screening from early phase with a drop of urine using C. elegans
Hirotsu T.
Brisbane Cancer Conference 2017(Nov, 2017)

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
Tokyo Metropolitan University(Nov, 2017)

Aiming for practical application of N-NOSE
Hirotsu T.
The Sawayaka Shinyo Kinko(Dec, 2017)

Cancer screening test using C. elegans
Hirotsu T.
Kojunsha(Dec, 2017)

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
The Sawayaka Shinyo Kinko(Dec, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Aflac Shiga(Dec, 2017)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
The Tokio Marine Life Insurance Co., Ltd. (Jan, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Metlife (Jan, 2018)

Diagnosis of Early cancer using olfaction of C. elegans
Hirotsu T.
Junshin Gakuen University(Feb, 2018)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
Tokyo Metropolitan Association of Medical Technologist(Feb, 2018)

Future of cancer screening test using olfaction of living
Hirotsu T.
National Institute of Advanced Industrial Science and Technology(AIST) Chub(Feb, 2018)

Talking about C. elegans and its experiment
Hirotsu T.
Mamoroom Fukuoka(Mar, 2018)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
Fukuoka ken judo Seifuku shikai (Mar, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Okasan Social Meeting(Mar, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
The Chemical Society of Japan(Mar, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
TY Financial Group(Mar, 2018)