研究実績

研究実績

論文 / Treatise

A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection
* Hirotsu T., Sonoda H., Uozumi T., Shinden Y., Mimori K., Maehara Y., Ueda N., Hamakawa M.
* Corresponding author
PLOS ONE, 10(3): e0118699 (2015)

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans
Uozumi T., Hamakawa M., Deno Y., Nakajo M., *Hirotsu T.
* Corresponding author
Genes to Cells, 20, 802-816 (2015)

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.
Hamakawa M., Uozumi T., Ueda N., Iino Y, *Hirotsu T.
* Corresponding author
BMC Biology, 13:6 (2015)

Cancer screening test using C. elegans scent detection.
*Hirotsu T.
* Corresponding author
Aroma Research, 16, 134-136 (2015) 

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.
Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., *Hirotsu T. * Corresponding author
Science Signaling, 7 (323), ra39 (2014)​

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.
*Hirotsu T.
* Corresponding author
Aroma Research, 15, 242-243 (2014)​

In vivo imaging of Ras protein’s activity in olfactory neurons.
Uozumi T., Yamada R., Suzuki A., Taniguchi G., Yoshida K., Iino Y., Ishihara T., *Hirotsu T.
* Corresponding author
Protocol Exchange, 2013, 011 (2013)​

Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.
1Uozumi T., 1*Hirotsu T., Yoshida K., Yamada R., Suzuki A., Taniguchi G., Iino Y., and Ishihara T.
1 同等貢献  * Corresponding author
(Nature) Scientific Reports, 2, 500 (2012) ​

Odour concentration-dependent olfactory preference change in C. elegans.
Yoshida K., *Hirotsu T., Tagawa T., Oda S., Wakabayashi T., Iino Y., and Ishihara T.
* Corresponding author
Nature Communications, 3, 739 (2012) 

Live imaging of signaling protein’s activity responding to odorant stimuli.
Uozumi T., *Hirotsu T. * Corresponding author Aroma Research, 13, 244 (2012) 

Neural mechanisms of olfactory preference change depending on the odor concentration.
Yoshida K., *Hirotsu T.  * Corresponding author
Aroma Research, 13, 137 (2012)

Scent aroma derived from woods: the consideration based on the physiological and psychological effects.
Shimizu K., Hirotsu T. (16人中8番目) et al.
Aroma Research, 13, 202-208 (2012)

Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans.
Shinkai Y., Yamamoto Y., Fujiwara M., Tabata T., Murayama T., Hirotsu T., Ikeda D., Tsunozaki M., Iino Y., Bargmann C., Katsura I., and Ishihara T.
Journal of Neuroscience, 31, 3007-3015 (2011)

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
Yamada K., Hirotsu T., Matsuki M., Butcher A., Tomioka M., Ishihara T., Clardy J., Kunitomo H. and Iino Y.
Science, 329, 1647-1650 (2010)

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H., Ishihara T., Iino Y. and Kubo T.
Nature Neuroscience, 12, 981-987 (2009)

Behavioural assay for olfactory plasticity in C. elegans.
Hirotsu T., Hayashi Y., Iwata R., Kunitomo H., Kage-Nakadai E., Kubo T., Ishihara T. and Iino Y.
Nature Protocols, 2009, 139 (2009)

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.
Yamada K., Hirotsu T., Matsuki M., Kunitomo H. and Iino Y.
Genetics, 181, 1347-1357 (2009) 

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.
Hirotsu T. and Iino Y.
Genes to Cells, 10, 517-530 (2005)

MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive neurites in Caenorhabditis elegans.
Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.
Current Biology, 15, 1554-1559 (2005)

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.
Hirotsu T., Saeki S., Yamamoto M. and Iino Y.
Nature, 404, 289-93 (2000)

Novel functions of the Ras-MAPK signal transduction pathway in neurons of C. elegans.
Hirotsu T., Saeki S. and Iino Y.
Worm Breeder’s Gazette,15, 41 (1999)

電位依存性アニオンチャネルVDAC-1は線虫C. elegansの嗅覚シグナル伝達において重要な働きを持つ
魚住隆行、出野結己、*広津崇亮  (*責任著者)
味と匂学会論文集, 21, 3 (2014)

匂いの濃度に依存した嗅覚受容体の使い分け機構の解明
谷口群、濱川昌之、魚住隆行、桐山恵介、紙崎智子、*広津崇亮  (*責任著者)
味と匂学会論文集, 21, 3 (2014)

総説・著書

A new method for time and cell-specific RNAi
Hamakawa M., Hirotsu T
Methods in Molecular Biology, in press (2015)

生物そのものを利用したバイオセンサ-線虫嗅覚によるがん診断-
広津崇亮
Journal of Japan Association on Odor Environment 46, 191-199 (2015)

尿1滴で短時間・安価・高精度に早期がんを診断!(がんの早期発見・早期治療に向けて)
広津崇亮
B & I 73, 487-488 (2015)

微量な尿からがんを診断する技術の開発
広津崇亮
技術情報協会 印刷中 (2015)

線虫を使ったがん診断の有用性
日本医事新報 印刷中 (2015)

においと私
広津崇亮
Journal of Japan Association on Odor Environment 印刷中 (2015)

線虫嗅覚により尿で早期がんを診断する方法
広津崇亮
學士会 914, 82-85 (2015)

嗅覚受容とMAPキナーゼ
広津崇亮
Clinical Neuroscience 31, 669-672 (2013)

線虫C. elegansにおける嗅覚受容体の網羅的解析
広津崇亮、谷口群、桐山恵介、紙崎智子、佐藤則子、石原健
21世紀の遺伝学 VIII, 5 (2012) 

線虫C. elegans における匂いの濃度に依存した行動変化を制御する神経回路の解明
吉田和史、広津崇亮、飯野雄一、石原健
21世紀の遺伝学 V, 5 (2008)

線虫における化学感覚と化学走性行動
飯野雄一、広津崇亮
実験医学 18, 2314-2319 (2000)

PAGE TOP