研究業績

-ORIGINAL PAPERS- 論文

A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection
*Hirotsu T., Sonoda H., Uozumi T., Shinden Y., Mimori K., Maehara Y., Ueda N., Hamakawa M.
* Corresponding author
PLOS ONE, 10(3): e0118699 (2015)

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans
Uozumi T., Hamakawa M., Deno Y., Nakajo M., *Hirotsu T.
* Corresponding author
Genes to Cells, 20, 802-816 (2015)

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.
Hamakawa M., Uozumi T., Ueda N., Iino Y, *Hirotsu T.
* Corresponding author
BMC Biology, 13:6 (2015)

Cancer screening test using C. elegans scent detection.
*Hirotsu T.
* Corresponding author
Aroma Research, 16, 134-136 (2015)

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.
Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., *Hirotsu T.
* Corresponding author
Science Signaling, 7 (323), ra39 (2014)

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.
*Hirotsu T. * Corresponding author
Aroma Research, 15, 242-243 (2014)

電位依存性アニオンチャネルVDAC-1は線虫C. elegansの嗅覚シグナル伝達において重要な働きを持つ
魚住隆行、出野結己、*広津崇亮
味と匂学会論文集, 21, 3 (2014)

匂いの濃度に依存した嗅覚受容体の使い分け機構の解明
谷口群、濱川昌之、魚住隆行、桐山恵介、紙崎智子、*広津崇亮
味と匂学会論文集, 21, 3 (2014)

In vivo imaging of Ras protein’s activity in olfactory neurons.
Uozumi T., Yamada R., Suzuki A., Taniguchi G., Yoshida K., Iino Y., Ishihara T., *Hirotsu T.
* Corresponding author
Protocol Exchange, 2013, 011 (2013)

Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.
1Uozumi T., 1*Hirotsu T., Yoshida K., Yamada R., Suzuki A., Taniguchi G., Iino Y., and Ishihara T.
1 equally contributed
* Corresponding author
(Nature) Scientific Reports, 2, 500 (2012)

Odour concentration-dependent olfactory preference change in C. elegans.
Yoshida K., *Hirotsu T., Tagawa T., Oda S., Wakabayashi T., Iino Y., and Ishihara T.
* Corresponding author
Nature Communications, 3, 739 (2012)

Live imaging of signaling protein’s activity responding to odorant stimuli.
Uozumi T., *Hirotsu T.
* Corresponding author
Aroma Research, 13, 244 (2012)

Neural mechanisms of olfactory preference change depending on the odor concentration.
Yoshida K., *Hirotsu T.
Aroma Research, 13, (2012)

Scent aroma derived from woods: the consideration based on the physiological and psychological effects.
Shimizu K., Hirotsu T. et al.
Aroma Research, 13, 202-208 (2012)

線虫C. elegansにおける嗅覚受容体の網羅的解析
*広津崇亮、谷口群、桐山恵介、紙崎智子、佐藤則子、石原健
21世紀の遺伝学 Ⅷ, 5 (2012)

Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans.
Shinkai Y., Yamamoto Y., Fujiwara M., Tabata T., Murayama T., Hirotsu T., Ikeda D., Tsunozaki M.,
Iino Y., Bargmann C., Katsura I., and Ishihara T.
Journal of Neuroscience, 31, 3007-3015 (2011)

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.
Yamada K., Hirotsu T., Matsuki M., Butcher A., Tomioka M., Ishihara T., Clardy J., Kunitomo H. and Iino Y.
Science, 329, 1647-1650 (2010)

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.
Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H., Ishihara T., Iino Y. and Kubo T.
Nature Neuroscience, 12, 981-987 (2009)

Behavioural assay for olfactory plasticity in C. elegans.
Hirotsu T., Hayashi Y., Iwata R., Kunitomo H., Kage-Nakadai E., Kubo T., Ishihara T. and Iino Y.
Nature Protocols, 2009, 139 (2009)

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.
Yamada K., Hirotsu T., Matsuki M., Kunitomo H. and Iino Y.
Genetics, 181, 1347-1357 (2009)

線虫C. elegansにおける匂いの濃度に依存した行動変化を制御する神経回路の解明
吉田和史、*広津崇亮、飯野雄一、石原健
21世紀の遺伝学 Ⅴ, 5 (2008)

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.
Hirotsu T. and Iino Y.
Genes to Cells, 10, 517-530 (2005)

MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive
neurites in Caenorhabditis elegans.
Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.
Current Biology, 15, 1554-1559 (2005)

線虫の嗅覚応答におけるRas-MAPK経路の機能に関する研究
広津崇亮
(学位論文 : 東京大学大学院 2001年3月)

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.
Hirotsu T., Saeki S., Yamamoto M. and Iino Y.
Nature,
404, 289-93 (2000)

Novel functions of the Ras-MAPK signal transduction pathway in neurons of C. elegans.
Hirotsu T., Saeki S. and Iino Y.
Worm Breeder’s Gazette,15, 41 (1999)

 

-REVIEWS- 総説・著書

線虫の嗅覚による早期がんの検出法N-NOSE
海渕覚、広津崇亮
システム/制御/情報 Vol.62 No.12 (2018)

線虫の嗅覚を利用したがん検査N-NOSEの発明と実用化
広津崇亮
安定同位体と生体ガス Vol.10 No.1 (2018)

線虫C. elegansの嗅覚研究とがん検査への応用
濱川昌之、*広津崇亮
Aroma Research, 19(4), 296-297 (2018)

線虫嗅覚を用いたがんスクリーニングの実用化に向けて
松原和子、*広津崇亮
Aroma Research, 19(3), 222-223 (2018)

Cancer diagnosis by odorants
Hirotsu T.
“Diseases of sensory organs” Japan Medical Association Section 6(2018)

線虫嗅覚によるがん検査
魚住隆行、広津崇亮
“New development of medical care of cancer” CMC Section 2-5(2017)

尿をもちいたがん診断技術と高感度化
海渕覚、広津崇亮
技術情報協会 (2017)

ここで線虫愛を語ってください
広津崇亮
生物工学会誌 Vol.95 6, 345-347 (2017)

線虫嗅覚を利用したがん検査システム
魚住隆行、広津崇亮
“Next-generation research of cancer” NTS Section 4-2(2017)

線虫嗅覚を利用した早期がん診断の可能性
広津崇亮
Pharma Medica 34, 33-38(2016)

匂い物質によるがん診断
広津崇亮
Clinical Neuroscience 嗅覚-New horizon Vol.34, 12 (2016)

微量な尿からがんを診断する技術の開発
広津崇亮
技術情報協会 (2016)

A new method for time and cell-specific RNAi
Hamakawa M., Hirotsu T.
Methods in Molecular Biology, 1507(67-79) (2016)

線虫を用いた新規がん診断法の開発
広津崇亮
血液フロンティア Vol.26, No.1 1423-1429 (2016)

線虫嗅覚を用いた高精度がん検出法
広津崇亮
ヘルスケアを支えるバイオ計測  112-120 (2016)

線虫を用いたがん診断
広津崇亮
生体の科学 Vol.67, No.2 178-183 (2016)

線虫嗅覚を利用した早期がん検出法
広津崇亮
BIO INDUSTORY Vol.33, No.5 3-10 (2016)

線虫を使ったがん診断の有用性
広津崇亮
日本医事新報 Vol.4791, 63-64 (2016)

線虫を用いて明らかにするにおいの濃度によって嗜好性が変化する仕組み
広津崇亮
におい・かおり環境学会誌 Vol.47, No.1 2-9 (2016)

偶然出会ったにおい研究
広津崇亮
におい・かおり環境学会誌 Vol.47, No.1 44 (2016)

Bio-sensor -Cancer diagnosis using olfaction of C. elegans-
Hirotsu T.
Journal of Japan Association on Odor Environment 46, 191-199 (2015)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
B & I 73, 487-488 (2015)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Gakushikai 914, 82-85 (2015)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Human-Health-Future 7, 30-37 (2015)

Olfactory receptor and Ras/MAP Kinase
Hirotsu T.
Clinical Neuroscience 31, 669-672 (2013)

The Ras-MAPK signal transduction pathway plays multiple roles in chemotaxis to odorants
Iino Y., Hirotsu T
Experimental Medicine 18, 2314-2319 (2000)

-INVITED LECTURES- 招待講演

The Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.
Hirotsu T.
World DNA and Genome Day(April, 2013)

The Ras-MAPK pathway plays multiple roles in the olfactory systems of C. elegans.
Hirotsu T.
World Gene Convention(Nov, 2013)

A highly accurate cancer diagnosis system using C. elegans scent detection
Hirotsu T., Sonoda H, Uozumi T, Mimori K, Maehara Y, Hamakawa M
12th ISMNTOP(Dec, 2014)

Cancer detecting using olfaction of C. elegans and the future of biosensor
Hirotsu T.
Kurume Research Park(May, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Aflac Fukuoka (July, 2015)

Cancer detecting by C. elegans
Hirotsu T.
Aflac Osaka (July, 2015)

Development of cancer detecting using olfaction of C. elegans
Hirotsu T.
OPACK(Kyushu University) (July, 2015)

Cancer detecting by C. elegans
Hirotsu T.
Kyushu Environmental Evaluation Association(Aug, 2015)

Talking about C. elegans and its experiment
Hirotsu T.
Mamoroom Fukuoka(Aug, 2015)

Olfaction of C. elegans and its possibility
Hirotsu T.
Society of Evolutionary Studies, Japan(Aug, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Nikkei Digital Health (Sep, 2015)

Diagnose cancer using only one drop of urine!
Hirotsu T.
Club Kansai(Sep, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Japan Health Foundation (Sep, 2015)

Cancer screening test using C. elegans
Hirotsu T.
Houken Kansai Corp.(Nov, 2015)

Cancer screening test using C. elegans and my career development
Hirotsu T.
Yamaguchi University(Nov, 2015)

A method of cancer detecting using olfaction of C. elegans
Hirotsu T.
Kyushu University(Nov, 2015)

Invention and Future for cancer-detecting test, N-NOSE
Hirotsu T.
Kanagawa R&D Promotion Council(Dec, 2015)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Farmers(Dec, 2015)

Cancer diagnosis using C. elegans
Hirotsu T.
18th UTP Symposium(Jan, 2016)

Doctor of C. elegans. Diagnose using only one drop of urine!
Hirotsu T.
Kyushu University Reunion in Kansai Area(Jan, 2016)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Aflac Fukuoka(Feb, 2016)

Doctor of C. elegans.
Hirotsu T.
Itoshima Science Caravan(Feb, 2016)

Doctor of C. elegans. Diagnose cancer using only one drop of urine!
Hirotsu T.
Tagawa Shinkin Group(Feb, 2016)

Invention and Future for cancer-detecting test, N-NOSE
Hirotsu T.
AGC Asahi Glass(Mar, 2016)

A highly accurate cancer diagnosis system using nematode scent detection (n-nose)
Hirotsu T.
AMED-NIH cancer workshop(Mar, 2016)

Invention and Future for cancer-detecting test, N-NOSE
Hirotsu T.
Japan Society of Clinical Proteome(May, 2016)

Diagnosis of Early cancer using olfaction of C. elegans
Hirotsu T.
Kumamoto University(May, 2016)

Detecting early-cancer using one drop of urine by C. elegans
Hirotsu T.
「Innovation of Amazing livings」Japan Bioindustry Association(July, 2016)

Detecting early-cancer using one drop of urine by C. elegans
Hirotsu T.
Aflac(Sep, 2016)

Development of cancer diagnose system using olfaction of C. elegans
Hirotsu T.
14th Medical Device Forum(Sep, 2016)

Future of the method of cancer screening test using C. elegans
Hirotsu T.
Aflac(Oct, 2016)

Future of cancer screening test using olfaction of living
Hirotsu T.
Aroma Science Forum(Oct, 2016)

Practical application for cancer-detecting test, N-NOSE
Hirotsu T.
JAMT Congress, Kanto-Koshinetsu (Oct, 2016

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
Kumamoto University(Oct, 2016)

Cancer screening test using C. elegans
Hirotsu T.
Houken Corp.(Oct, and Nov, 2016)

Detecting early-cancer using C. elegans
Hirotsu T.
Japan Gastroenterological Endoscopy Society(Nov, 2016)

Cancer at present and future
Hirotsu T.
Douyukai Representative Steering Committee(Dec, 2016)

Lecture and Experiment for C. elegans
Hirotsu T.
Mamoroom Fukuoka(Jan, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Kita-Kyushu Chamber of Commerce and Industry(Aug, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T
Aflac(Mar, 2017)

Cancer screening test using C. elegans
Hirotsu T.
Houken Kansai Corp.(May, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Metlife (May, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Biochemical Assay Society of Japan(June, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Aflac, Osaka(July, 2017)

Aiming for practical application of N-NOSE
Hirotsu T.
Osaka Kosei Shinyo Kinko(July, 2017)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
Tosu Miyaki Medical Association(Aug, 2017)

Venture start-up and corporate activities aiming for practical application of N-NOSE
Hirotsu T.
Kita-Kyushu Chamber of Commerce and Industry(Aug, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Japan University Health Association in Kyushu Area(Aug, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Tokushima Young Investigators Conference(Sep, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Japanese society for disease of the colon and rectum in Saitama(Sep, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Japan Society for Medical Application of Stable Isotope and Biogas(Sep, 2017)

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
The Hitachi Global Foundation(Oct, 2017)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
The Tokio Marine Life Insurance Co., Ltd. (Oct, 2017)

R&D of Cancer screening test using C. elegans
Hirotsu T.
Houken Corp.(Oct, 2017)

R&D of Cancer screening test using C. elegans
Hirotsu T.
Houken Chubu Corp.(Nov, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Aflac Osaka(Nov, 2017)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Kyoto Independent Insurance Agent Association(Nov, 2017)

N-NOSE: Cancer screening from early phase with a drop of urine using C. elegans
Hirotsu T.
Brisbane Cancer Conference 2017(Nov, 2017)

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
Tokyo Metropolitan University(Nov, 2017)

Aiming for practical application of N-NOSE
Hirotsu T.
The Sawayaka Shinyo Kinko(Dec, 2017)

Cancer screening test using C. elegans
Hirotsu T.
Kojunsha(Dec, 2017)

Screening of early cancer with one drop of urine using C. elegans
Hirotsu T.
The Sawayaka Shinyo Kinko(Dec, 2017)

Detecting early cancer method using olfaction of C. elegans
Hirotsu T.
Aflac Shiga(Dec, 2017)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
The Tokio Marine Life Insurance Co., Ltd. (Jan, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Metlife (Jan, 2018)

Diagnosis of Early cancer using olfaction of C. elegans
Hirotsu T.
Junshin Gakuen University(Feb, 2018)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
Tokyo Metropolitan Association of Medical Technologist(Feb, 2018)

Future of cancer screening test using olfaction of living
Hirotsu T.
National Institute of Advanced Industrial Science and Technology(AIST) Chub(Feb, 2018)

Talking about C. elegans and its experiment
Hirotsu T.
Mamoroom Fukuoka(Mar, 2018)

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!
Hirotsu T.
Fukuoka ken judo Seifuku shikai (Mar, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
Okasan Social Meeting(Mar, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
The Chemical Society of Japan(Mar, 2018)

Invention and practical application for cancer-detecting test, N-NOSE
Hirotsu T.
TY Financial Group(Mar, 2018)

 

CONFERENCE PRESENTATIONS

Involvement of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan (Dec, 1998)

  • Novel functions of the Ras-MAPK signal in neurons of C. elegans.

Hirotsu T., et al.

International C. elegans meeting (Jul, 1999)

  • Functions of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan (Dec, 1999)

  • Involvement of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Neuroscience Society (Jun, 2000)

  • Multiple roles for the Ras-MAPK signal transduction pathway in chemotaxis to odorants?

Hirotsu T., et al.

West Coast Worm Meeting (Jun, 2000)

  • The Ras-MAPK signal transduction pathway plays multiple roles in chemotaxis to odorants.

Hirotsu T., et al.

Japanese Worm Meeting (Aug, 2000)

  • Involvement of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan (Dec, 2000)

  • THE RAS⁄MAP KINASE PATHWAY IS INVOLVED IN OLFACTION IN CAENORHABDITIS ELEGANS.

Hirotsu T., et al.

Annual Meeting of Society for Neuroscience(Dec, 2000)

  • Multiple roles of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan (Dec, 2001)

  • The Ras-MAPK pathway acts in interneurons for olfactory plasticity.

Hirotsu T., et al.

West Coast Worm Meeting (Jul, 2002)

  • The Ras-MAPK signal transduction pathway is important for olfactory plasticity.

Hirotsu T., et al.

Japanese Worm Meeting (Jul, 2002)

 

Multiple roles of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al. The Molecular Biology Society of Japan (Dec, 2002)

  • Mechanisms of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Genetics society (Oct, 2003)

  • Mechanisms of olfactory plasticity of C. elegans: Regulation of localization of glutamate receptors

Hirotsu T., et al.

The Molecular Biology Society of Japan (Dec, 2003)

  • The Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans

Hirotsu T., et al.

Neuro2004 (Jun, 2004)

  • The Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans

Hirotsu T., et al.

International C. elegans Meeting (Jun, 2005)

  • Mechanisms of olfactory plasticity of C. elegans: Regulation of localization of glutamate receptors

Hirotsu T., et al.

The Japan Genetics society (Oct, 2005)

  • Mechanisms of neural circuit-dependent olfactory adaptation of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan (Dec, 2005)

  • Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans

Hirotsu T., et al.

Neuro2006 (Jun, 2006)

  • GLR-1 glutamate receptor is regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation.

Hirotsu T., et al.

East Asia C. elegans Meeting (Nov, 2006)

  • GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.

Hirotsu T., et al.

Neuro2007(Jun, 2007)

  • Mechanisms of neural circuit-dependent olfactory adaptation of C. elegans

Hirae S., Hirotsu T., et al.

BMB2007(Dec, 2007)

  • Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans

Hirotsu T., et al.

BMB2007(Dec, 2007)

  • Neural circuit-dependent odor adaptation in elegansis regulated by the Ras-MAPK pathway.

Maeda K., Hirotsu T., et al.

BMB2008(Dec, 2008)

  • Live imaging of Ras activity in olfactory neurons in C. elegans.

Hirotsu T., et al.

International C. elegans Meeting(Jun, 2009)

  • Systematic identification of specific receptors for odorants in C. elegans.

Kiriyama K., Hirotsu T., et al.

International C. elegans Meeting(Jun, 2009)

  • Olfactory adaptation is regulated by a peptide signal in C. elegans.

Yamada K., Hirotsu T., et al.

International C. elegans Meeting(Jun, 2009)International, Oral presentation

  • Live imaging of Ras activity in olfactory neurons in C. elegans.

*Hirotsu T., et al.

International Symposium on Cellular Signaling(Jan, 2009)International, Oral presentation

  • Live imaging of Ras activity in olfactory neurons in C. elegans.

Uozumi T., Hirotsu T., et al.

The Molecular Biology Socity of Japan(Dec, 2009)

  • Ascaroside Pheromones Regulate Olfactory Plasticity through the SNET-1 Peptide.

Yamada K., Hirotsu T., et al.

  1. elegans Neuro(Jul, 2010)
  • Neural and Behavioral Mechanisms of Response to an Odorant Depending on its Concentration.

Yoshida K., Hirotsu T., et al.

  1. elegans Neuro(Jul, 2010)
  • Live imaging of Ras activity in olfactory systems in C. elegans.

Uozumi T., Hirotsu T., et al.

  1. elegans Neuro(Jul, 2010)
  • Ascaroside Pheromones Regulate Olfactory Plasticity through the SNET-1 Peptide.

Yamada K., Hirotsu T., et al.

East Asia C. elegans Meeting(Jul, 2010)

  • Neural and Behavioral Mechanisms of Response to an Odorant Depending on its Concentration.

Yoshida K., Hirotsu T., et al

East Asia C. elegans Meeting(Jul, 2010)

  • Live imaging of Ras activity in olfactory neurons in C. elegans.

Hirotsu T., et al.

Imaging Workshop(Aug, 2010)Invited presentation

  • Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.

Hirotsu T. et al.

BMB2010(Dec, 2010)

  • Live imaging of Ras activity in olfactory neurons in C. elegans.

Uozumi T., Hirotsu T., et al.

BMB2010(Dec, 2010)

  • Olfactory preference switch depending on odor concentration is mediated by combinatorial change of acting sensory neurons

Yoshida K., Hirotsu T., et al.

International Worm Meeting(Jun, 2011)

  • In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Hirotsu T., et al.

Japan Society for Cell Biology(Jun, 2011)

  • Coordinated change of acting sensory neurons is important for olfactory preference change depending upon odor concentration

Yoshida K., Hirotsu T., et al.

Neuroscience2011(Sep, 2011)

  • In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Uozumi T., Hirotsu T., et al.

Neuroscience2011(Sep, 2011)

  • Systematic identification of olfactory receptor for odorants in C. elegans

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Ishihara T., Hirotsu T.

The Molecular Biology Society of Japan(Dec, 2011)

  • In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Uozumi T., Hirotsu T., et al.

The Molecular Biology Society of Japan(Dec, 2011)

  • In vivo Imaging of Ras Activity in Olfactory Neurons Suggests its Transient Activation is Important for Olfactory Behavior

Uozumi T., Hirotsu T., et al.

East Asia Worm Meeting(Jun, 2012)

  • Systematic identification of olfactory receptors for odorants

Taniguchi G., Kiriyama K., Kamizaki T., Noriko S., and Hirotsu T.

East Asia Worm Meeting(Jun, 2012)

  • Neuronal mechanisms underlying olfactory preference change depending upon odor concentration

Yoshida K., Hirotsu T., et al.

ISOT(International Symposium on Olfaction and Taste) (Jun, 2012)

  • Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Hirotsu T.

The Genetics Society of Japan(Sep, 2012)

  • A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.

Hamakawa M., Iino Y., Hirotsu T.

The Genetics Society of Japan(Sep, 2012)

  • Systematic identification of specific receptors for odorants in C. elegans.

Matsuo T., Hirotsu T.

The Genetics Society of Japan(Sep, 2012)

  • In vivo Imaging Reveals Regulatory Mechanisms and Functions of Ras Activity in Olfactory Neurons

Uozumi T., Hirotsu T., et al.

Neuroscience2012(Sep, 2012)

  • In vivo Imaging Reveals Regulatory Mechanisms and Functions of Ras Activity in Olfactory Neurons

Uozumi T., Hirotsu T., Yoshida K., Yamada R., Suzuki A., Iino Y., Ishihara T.

The Molecular Biology Society of Japan(Dec, 2012)

  • The Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M. Iino Y., Hirotsu T.

The Molecular Biology Society of Japan(Dec, 2012)

  • Systematic identification of specific receptors for odorants in C. elegans.

Matsuo T., Hirotsu T., et al.

The Molecular Biology Society of Japan(Dec, 2012)

  • Comprehensive analysis of olfactory receptors in C. elegans

Uozumi T., Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Ishihara T., *Hirotsu T.,

The Molecular Biology Society of Japan(Dec, 2012)

  • The Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.

Hirotsu T.

World DNA and Genome Day(Apr, 2013)Invited presentation

  • The Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M. Iino Y., Hirotsu T.

Neuro2013(Jun, 2013)

  • Screening of odor-receptor pairs reveals concentration-dependent switches in olfactory receptors

Uozumi T., Taniguci G., Kiriyama K., Kamizaki T., Hirotsu T.

Neuro2013(Jun, 2013)

  • The Ras-MAPK pathway plays multiple roles in the olfactory systems of C. elegans.

Hirotsu T.

World Gene Convention(Nov, 2013)Invited presentation

  • The consideration based on the physiological and psychological effects.

Matsuo T., Shimizu K., Okamoto G., Hirotsu T. et al.

The Molecular Biology Society of Japan(Dec, 2013)

  • The Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.

Matsuo T., Hirotsu T.

The Molecular Biology Society of Japan(Dec, 2012)

  • The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.

Hamakawa M., Iino Y., Hirotsu T.

The Molecular Biology Society of Japan(Dec, 2012)

  • Analysis of functions of LET-60Ras in regulation of exploratory behavior by a novel method, time- and cell-specific RNAi.

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

The 6th Asia-pacific C. elegans Meeting(Jun, 2014)

  • A novel method, time- and cell-specific RNAi, revealed the function of Ras in neurons regulating exploratory behavior oral presentation

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

Neuro2014 (Jul, 2014)

  • The neural circuit mechanisms regulating olfactory preference change (olfactory central adaptation) after odor experience in C. elegans

Ueda N, Matsuo T, Hirotsu T.

The Genetics Society of Japan(Sep, 2014)

  • Switching of olfactory receptors depending on odor concentrations in C. elegans

Taniguchi G, Hamakawa M, Uozumi T, Kiriyama K, Kamizaki T, Hirotsu T.

The Japanese Association for the Study of Taste and Smell(Nov, 2014)

  • Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Deno Y., Hirotsu T.

The Japanese Association for the Study of Taste and Smell(Nov, 2014)

  • Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Deno Y., Hirotsu T.

The Molecular Biology Society of Japan(Dec, 2014)

  • The neural circuit mechanisms regulating olfactory preference change (olfactory central adaptation) after odor experience in C. elegans

Ueda N, Matsuo T, Hirotsu T.

12th ISMNTOP(Dec, 2014)

  • Switching of olfactory receptors depending on odor concentrations in C. elegans

Taniguchi G, Hamakawa M, Uozumi T, Kiriyama K, Kamizaki T, Hirotsu T.

12th ISMNTOP(Dec, 2014)

  • A highly accurate cancer diagnosis system using C. elegans scent detection

Hirotsu T., Sonoda H, Uozumi T, Mimori K, Maehara Y, Hamakawa M

12th ISMNTOP(Dec, 2014)Invited presentation

  • Cancer screening test using C. elegans scent detection.

Sonoda H., Hirotsu T., et al

Japan Society of Clinical Oncology(Oct, 2015)

  • Cancer screening test using C. elegans scent detection.

Sonoda H., Hirotsu T.

Japanese Cancer Association(Oct, 2015)

  • A novel method for time- and cell-specific RNAi revealed the profile of Let-60Ras in exploratory behavior

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

International C. elegans meeting(Jul, 2015)

  • The analysis of the neuropeptide signaling in the neural circuit-dependent odor adaptation

Ueda N, Matsuo T, Hirotsu T.

Neuro2015(Jul, 2015)

  • A novel method for Time- and Cell-specific RNAi reveals the temporal role of Ras in the motor neurons controlling exploratory behavior

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

Neuro2015(Jul, 2015)

  • Development of cancer detecting using olfaction of C. elegans

Hirotsu T.

OPACK(Kyushu University) (Jul, 2015)Invited lecture

  • Olfaction of C. elegans and its possibility

Hirotsu T.

Society of Evolutionary Studies, Japan(Aug, 2015)Invited lecture

  • A method of cancer detecting using olfaction of C. elegans

Hirotsu T.

Nikkei Digital Health (Sep, 2015)Invited lecture

  • Cancer diagnosis using C. elegans

Hirotsu T.

18th UTP Symposium(Jan, 2016)Invited lecture

  • A highly accurate cancer diagnosis system using nematode scent detection (n-nose)

Hirotsu T.

AMED-NIH cancer workshop(Mar, 2016)Invited lecture

  • Invention and Future for cancer-detecting test, N-NOSE

Hirotsu T.

Japan Society of Clinical Proteome(May, 2016)Invited lecture

  • Detecting early-cancer using one drop of urine by C. elegans

Hirotsu T.

「Innovation of Amazing livings」Japan Bioindustry Association(Jun, 2016)

Invited lecture

  • Development of cancer diagnose system using olfaction of C. elegans

Hirotsu T.

14th Medical Device Forum(Sep, 2016)Invited lecture

  • Future of cancer screening test using olfaction of living

Hirotsu T.

Aroma Science Forum(Oct, 2016)Invited lecture

  • Practical application for cancer-detecting test, N-NOSE

Hirotsu T.

JAMT Congress, Kanto-Koshinetsu (Nov, 2016)Invited lecture

  • Diagnosis of early cancer using C. elegans

Hirotsu T.

Japan gastrointestinal endoscopySociety(Nov, 2016)Invited lecture

  • Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Biochemical Assay Society of Japan(Jun, 2017)Invited lecture

  • Detecting early-cancer using one drop of urine.  Short time, low cost, and high accurate!

Hirotsu T.

Tosu Miyaki Medical Association(Aug, 2017)Invited lecture

  • Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japan University Health Association in Kyushu Area(Aug, 2017)Invited lecture

  • Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Tokushima Young Investigators Conference(Sep, 2017)Invited lecture

  • Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japanese society for disease of the colon and rectum in Saitama(Sep, 2017)

Invited lecture

  • Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japan Society for Medical Application of Stable Isotope and Biogas(Sep, 2017)

Invited lecture

  • Development of cancer screening test

Miyata K., Hirotsu T.

The Electrochemical Society of Japan(Sep, 2017)Invited lecture

  • N-NOSE: Cancer screening from early phase with a drop of urine using C. elegans

Hirotsu T.

Brisbane Cancer Conference 2017(Nov, 2017)Invited lecture

  • Detecting early-cancer using one drop of urine.  Short time, low cost, and high accurate!

Hirotsu T.

Tokyo Metropolitan Association of Medical Technologist(Feb, 2018)Invited lecture

  • Future of cancer screening test using olfaction of living

Hirotsu T.

National Institute of Advanced Industrial Science and Technology(AIST) Chub(Feb, 2018)Invited lecture

  • Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

The Chemical Society of Japan(Mar, 2018)Invited lecture

  • Practical use of olfaction of C. elegans, N-NOSE

Uozumi T., Hirotsu T.

The Pharmaceutical Society of Japan(Mar, 2018)Invited lecture