Research & Development

ORIGINAL PAPERS

2018

Toward practical application of cancer screening using nematode scent discrimination.

Matsubara K. and *Hirotsu T.

Aroma Research, 19(3), 222-223

2015

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Hamakawa M., Deno Y., Nakajo M., *Hirotsu T.

Genes to Cells, 20, 802-816

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.

Hamakawa M., Uozumi T., Ueda N., Iino Y, *Hirotsu T.

BMC Biology, 13:6

A Highly Accurate Inclusive Cancer Screening Test Using Caenorhabditis elegans Scent Detection

*Hirotsu T., Sonoda H., Uozumi T., Shinden Y., Mimori K., Maehara Y., Ueda N., Hamakawa M.

PLOS ONE, 10(3): e0118699

Cancer screening test using C. elegans scent detection.

*Hirotsu T.

Aroma Research, 16, 134-136

2014

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.

Taniguchi G., Uozumi T., Kiriyama K., Kamizaki T., *Hirotsu T.

Science Signaling, 7 (323), ra39

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.

*Hirotsu T. * Corresponding author

Aroma Research, 15, 242-243

2013

In vivo imaging of Ras protein’s activity in olfactory neurons.

Uozumi T., Yamada R., Suzuki A., Taniguchi G., Yoshida K., Iino Y., Ishihara T., *Hirotsu T.

Protocol Exc hange, 2013, 011

2012

Comprehensive analysis of olfactory receptors in C. elegans

*Hirotsu T., Taniguchi G., Kiriyama K., Kamizaki T., Sato N. and Ishihara T.

Genetics in 21th Century, VIII, 12

Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour.

1Uozumi T., 1*Hirotsu T., Yoshida K., Yamada R., Suzuki A., Taniguchi G., Iino Y., and Ishihara T.

(Nature) Scientific Reports, 2, 500

Odour concentration-dependent olfactory preference change in C. elegans.

Yoshida K., *Hirotsu T., Tagawa T., Oda S., Wakabayashi T., Iino Y., and Ishihara T.

Nature Communications, 3, 739

Live imaging of signaling protein’s activity responding to odorant stimuli.

Uozumi T., *Hirotsu T.

Aroma Research, 13, 244

Scent aroma derived from woods: the consideration based on the physiological and psychological effects.

Shimizu K., Hirotsu T. et al.

Aroma Research, 13, 202-208

2011

Behavioral choice between conflicting alternatives is regulated by a receptor guanylyl cyclase GCY-28 and a receptor tyrosine kinase SCD-2 in AIA interneurons of C. elegans.

Shinkai Y., Yamamoto Y., Fujiwara M., Tabata T., Murayama T., Hirotsu T., Ikeda D., Tsunozaki M.,Iino Y., Bargmann C., Katsura I., and Ishihara T.

Journal of Neuroscience, 31, 3007-3015

2010

Olfactory plasticity is regulated by pheromonal signaling in Caenorhabditis elegans.

Yamada K., Hirotsu T., Matsuki M., Butcher A., Tomioka M., Ishihara T., Clardy J., Kunitomo H. and Iino Y.

Science, 329, 1647-1650

2009

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.

Hayashi Y., Hirotsu T., Iwata R., Kage-Nakadai E., Kunitomo H., Ishihara T., Iino Y. and Kubo T.

Nature Neuroscience, 12, 981-987

Behavioural assay for olfactory plasticity in C. elegans.

Hirotsu T., Hayashi Y., Iwata R., Kunitomo H., Kage-Nakadai E., Kubo T., Ishihara T. and Iino Y.

Nature Protocols, 2009, 139

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.

Yamada K., Hirotsu T., Matsuki M., Kunitomo H. and Iino Y.

Genetics, 181, 1347-1357

2008

Analysis of neural mechanisms of behavioral changes depending on odor concentrations

Yoshida K., *Hirotsu T., Ishihara T. and Iino Y.

Genetics in 21th Century, V, 5

2005

Neural circuit-dependent odor adaptation in C. elegans is regulated by the Ras-MAPK pathway.

Hirotsu T. and Iino Y.

Genes to Cells, 10, 517-530

MBR-1, a novel helix-turn-helix transcription factor, is required for pruning of excessive neurites in Caenorhabditis elegans.

Kage E., Hayashi Y., Takeuchi H., Hirotsu T., Kunitomo H., Inoue T., Arai H., Iino Y. and Kubo T.

Current Biology, 15, 1554-1559

2000

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.

Hirotsu T., Saeki S., Yamamoto M. and Iino Y.

Nature, 404, 289-93

1999

Novel functions of the Ras-MAPK signal transduction pathway in neurons of C. elegans.

Hirotsu T., Saeki S. and Iino Y.

Worm Breeder’s Gazette,15, 41

REVIEWS

2018

Cancer diagnosis by odorants

Hirotsu T.

“Diseases of sensory organs” Japan Medical Association Section 6

2017

Development of highly accurate cancer screening test using C. elegans

Uozumi T., Hirotsu T.

“New development of medical care of cancer” CMC Section 2-5

Diagnostic skills and sensitivity improvement using urine

Kaifuchi F., Hirotsu T.

“Early diagnosis of diseases” Technical Information Institute Co., Ltd. Section 5

Tell us about love for C. elegans.

Hirotsu T.

The Society for Bioscience and Bioengineering 6, 345-347

Cancer screening system using olfaction of C. elegans

Uozumi T., Hirotsu T.

“Next-generation research of cancer” NTS Section 4-2

2016

Possibility of early diagnostic of cancer using olfaction of C. elegans

Hirotsu T.

Pharma Medica 34, 33-38

Diagnostic of cancer by smell substances

Hirotsu T.

“Olfaction new horizon “ Clinical Neuroscience

Technical development for cancer diagnosis using a slight amount of urine

Hirotsu T.

“R&D of future treatment and diagnosis technique of cancer” Technical Information Institute Co., Ltd. Section 6

A new method for time and cell-specific RNAi

Hamakawa M., Hirotsu T.

Methods in Molecular Biology, 1507(67-79)

Technical development for new cancer diagnosis using C. elegans

Hirotsu T.

“Hematology Frontier” Medical and Drug Journal, Co., ltd. 26, 1423-1429

High accurate cancer-detecting method using C. elegans olfaction method

Hirotsu T.

“Bio-measuring supports health care” CMC 112-120

Cancer diagnosis using C. elegans

Hirotsu T.

「Science of Living」 67, 178-183

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

BIO INDUSTORY 33, 5, 3-10

Smell and Me

Hirotsu T.

Journal of Japan Association on Odor Environment 47, 44

Advantage of Cancer diagnosis using C. elegans

Hirotsu T.

Japan Medical Journal 4791, 63-64

Odour concentration-dependent olfactory preference change in C. elegans.

Hirotsu T.

Journal of Japan Association on Odor Environment 47, 2-9

2015

Bio-sensor -Cancer diagnosis using olfaction of C. elegans-

Hirotsu T.

Journal of Japan Association on Odor Environment 46, 191-199

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

B & I 73, 487-488

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Gakushikai 914, 82-85

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Human-Health-Future 7, 30-37

2013

Olfactory receptor and Ras / MAP Kinase

Hirotsu T.

Clinical Neuroscience 31, 669-672

2000

The Ras-MAPK signal transduction pathway plays multiple roles in chemotaxis to odorants

Iino Y., Hirotsu T

Experimental Medicine 18, 2314-2319

INVITED LECTURES

2018
Mar.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

TY Financial Group

Mar.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

The Chemical Society of Japan

Mar.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Okasan Social Meeting

Mar.

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

Fukuoka ken judo Seifuku shikai

Mar.

Talking about C. elegans and its experiment

Hirotsu T.

Mamoroom Fukuoka

Feb.

Future of cancer screening test using olfaction of living

Hirotsu T.

National Institute of Advanced Industrial Science and Technology(AIST) Chub

Feb.

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

Tokyo Metropolitan Association of Medical Technologist

Feb.

Diagnosis of Early cancer using olfaction of C. elegans

Hirotsu T.

Junshin Gakuen University

Jan.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Metlife

Jan.

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

The Tokio Marine Life Insurance Co., Ltd.

2017
Dec.

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Aflac Shiga

Dec.

Screening of early cancer with one drop of urine using C. elegans

Hirotsu T.

The Sawayaka Shinyo Kinko

Dec.

Cancer screening test using C. elegans

Hirotsu T.

Kojunsha

Dec.

Aiming for practical application of N-NOSE

Hirotsu T.

The Sawayaka Shinyo Kinko

Nov.

Screening of early cancer with one drop of urine using C. elegans

Hirotsu T.

Tokyo Metropolitan University

Nov.

N-NOSE: Cancer screening from early phase with a drop of urine using C. elegans

Hirotsu T.

Brisbane Cancer Conference 2017

Nov.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Kyoto Independent Insurance Agent Association

Nov.

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Aflac Osaka

Nov.

R&D of Cancer screening test using C. elegans

Hirotsu T.

Houken Chubu Corp.

Oct.

R&D of Cancer screening test using C. elegans

Hirotsu T.

Houken Corp.

Oct.

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

The Tokio Marine Life Insurance Co., Ltd.

Oct.

Screening of early cancer with one drop of urine using C. elegans

Hirotsu T.

The Hitachi Global Foundation

Sep.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japan Society for Medical Application of Stable Isotope and Biogas

Sep.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japanese society for disease of the colon and rectum in Saitama

Sep.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Tokushima Young Investigators Conference

Aug.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japan University Health Association in Kyushu Area

Aug.

Venture start-up and corporate activities aiming for practical application of N-NOSE

Hirotsu T.

Kita-Kyushu Chamber of Commerce and Industry

Aug.

Detecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

Tosu Miyaki Medical Association

Jul.

Aiming for practical application of N-NOSE

Hirotsu T.

Osaka Kosei Shinyo Kinko

Jul.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Aflac, Osaka

Jun.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Biochemical Assay Society of Japan

May.

Invention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Metlife

May.

Cancer screening test using C. elegans

Hirotsu T.

Houken Kansai Corp.

Mar.

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Aflac

Aug.

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Kita-Kyushu Chamber of Commerce and Industry

Jan.

Lecture and Experiment for C. elegans

Hirotsu T.

Mamoroom Fukuoka

2016
Dec.

Cancer at present and future

Hirotsu T.

Douyukai Representative Steering Committee

Nov.

Detecting early-cancer using C. elegans

Hirotsu T.

Japan Gastroenterological Endoscopy Society

Nov.

Cancer screening test using C. elegans

Hirotsu T.

Houken Corp.(Oct, and Nov, 2016)

Oct.

Screening of early cancer with one drop of urine using C. elegans

Hirotsu T.

Kumamoto University

Oct.

Practical application for cancer-detecting test, N-NOSE

Hirotsu T.

JAMT Congress, Kanto-Koshinetsu

Oct.

Future of cancer screening test using olfaction of living

Hirotsu T.

Aroma Science Forum

Oct.

Future of the method of cancer screening test using C. elegans

Hirotsu T.

Aflac

Sep.

Development of cancer diagnose system using olfaction of C. elegans

Hirotsu T.

14th Medical Device Forum

Sep.

Detecting early-cancer using one drop of urine by C. elegans

Hirotsu T.

Aflac

Jul.

Detecting early-cancer using one drop of urine by C. elegans

Hirotsu T.

「Innovation of Amazing livings」Japan Bioindustry Association

May.

Diagnosis of Early cancer using olfaction of C. elegans

Hirotsu T.

Kumamoto University

May.

Invention and Future for cancer-detecting test, N-NOSE

Hirotsu T.

Japan Society of Clinical Proteome

May.

A highly accurate cancer diagnosis system using nematode scent detection (n-nose)

Hirotsu T.

AMED-NIH cancer workshop

May.

Invention and Future for cancer-detecting test, N-NOSE

Hirotsu T.

AGC Asahi Glass

Feb.

Doctor of C. elegans. Diagnose cancer using only one drop of urine!

Hirotsu T.

Tagawa Shinkin Group

Feb.

Doctor of C. elegans.

Hirotsu T.

Itoshima Science Caravan

Feb.

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Aflac Fukuoka

Jan.

Doctor of C. elegans. Diagnose using only one drop of urine!

Hirotsu T.

Kyushu University Reunion in Kansai Area

Jan.

Cancer diagnosis using C. elegans

Hirotsu T.

18th UTP Symposium

2015
Dec.

Detecting early cancer method using olfaction of C. elegans

Hirotsu T.

Farmers

Dec.

Invention and Future for cancer-detecting test, N-NOSE

Hirotsu T.

Kanagawa R&D Promotion Council

Nov.

A method of cancer detecting using olfaction of C. elegans

Hirotsu T.

Kyushu University

Nov.

Cancer screening test using C. elegans and my career development

Hirotsu T.

Yamaguchi University

Nov.

Cancer screening test using C. elegans

Hirotsu T.

Houken Kansai Corp.

Sep.

A method of cancer detecting using olfaction of C. elegans

Hirotsu T.

Japan Health Foundation

Sep.

Diagnose cancer using only one drop of urine!

Hirotsu T.

Club Kansai

Sep.

A method of cancer detecting using olfaction of C. elegans

Hirotsu T.

Nikkei Digital Health

Aug.

Olfaction of C. elegans and its possibility

Hirotsu T.

Society of Evolutionary Studies, Japan

Aug.

Talking about C. elegans and its experiment

Hirotsu T.

Mamoroom Fukuoka

Aug.

Cancer detecting by C. elegans

Hirotsu T.

Kyushu Environmental Evaluation Association

Jul.

Development of cancer detecting using olfaction of C. elegans

Hirotsu T.

OPACK(Kyushu University)

Jul.

Cancer detecting by C. elegans

Hirotsu T.

Aflac Osaka

Jul.

A method of cancer detecting using olfaction of C. elegans

Hirotsu T.

Aflac Fukuoka

May.

Cancer detecting using olfaction of C. elegans and the future of biosensor

Hirotsu T.

Kurume Research Park

May.

Cancer detecting using olfaction of C. elegans and the future of biosensor

Hirotsu T.

Kurume Research Park

2014
Dec.

A highly accurate cancer diagnosis system using C. elegans scent detection

Hirotsu T., Sonoda H, Uozumi T, Mimori K, Maehara Y, Hamakawa M

12th ISMNTOP

2013
Nov.

The Ras-MAPK pathway plays multiple roles in the olfactory systems of C. elegans.

Hirotsu T.

World Gene Convention

Apr.

The Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.

Hirotsu T.

World DNA and Genome Day

CONFERENCE PRESENTATIONS

2018
Mar.

Invited lecturePractical use of olfaction of C. elegans, N-NOSE

Uozumi T., Hirotsu T.

The Pharmaceutical Society of Japan

Mar.

Invited lectureInvention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

The Chemical Society of Japan

Feb.

Invited lectureFuture of cancer screening test using olfaction of living

Hirotsu T.

National Institute of Advanced Industrial Science and Technology(AIST) Chub

Feb.

Invited lectureDetecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

Tokyo Metropolitan Association of Medical Technologist

2017
Nov.

Invited lectureN-NOSE: Cancer screening from early phase with a drop of urine using C. elegans

Hirotsu T.

Brisbane Cancer Conference 2017

Sep.

Invited lectureDevelopment of cancer screening test

Miyata K., Hirotsu T.

The Electrochemical Society of Japan

Sep.

Invited lectureInvention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japan Society for Medical Application of Stable Isotope and Biogas

Sep.

Invited lectureInvention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japanese society for disease of the colon and rectum in Saitama

Sep.

Invited lectureInvention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Tokushima Young Investigators Conference

Aug.

Invited lectureInvention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Japan University Health Association in Kyushu Area

Aug.

Invited lectureDetecting early-cancer using one drop of urine. Short time, low cost, and high accurate!

Hirotsu T.

Tosu Miyaki Medical Association

Jun.

Invited lectureInvention and practical application for cancer-detecting test, N-NOSE

Hirotsu T.

Biochemical Assay Society of Japan

2016
Nov.

Invited lectureDiagnosis of early cancer using C. elegans

Hirotsu T.

Japan gastrointestinal endoscopySociety

Nov.

Invited lecturePractical application for cancer-detecting test, N-NOSE

Hirotsu T.

JAMT Congress, Kanto-Koshinetsu

Oct.

Invited lectureFuture of cancer screening test using olfaction of living

Hirotsu T.

Aroma Science Forum

Sep.

Invited lectureDevelopment of cancer diagnose system using olfaction of C. elegans

Hirotsu T.

14th Medical Device Forum

Jun.

Invited lectureDetecting early-cancer using one drop of urine by C. elegans

Hirotsu T.

「Innovation of Amazing livings」Japan Bioindustry Association

May.

Invited lectureInvention and Future for cancer-detecting test, N-NOSE

Hirotsu T.

Japan Society of Clinical Proteome

Mar.

Invited lectureA highly accurate cancer diagnosis system using nematode scent detection (n-nose)

Hirotsu T.

AMED-NIH cancer workshop

Jan.

Invited lectureCancer diagnosis using C. elegans

Hirotsu T.

18th UTP Symposium

2015
Sep.

Invited lectureA method of cancer detecting using olfaction of C. elegans

Hirotsu T.

Nikkei Digital Health

Aug.

Invited lectureOlfaction of C. elegans and its possibility

Hirotsu T.

Society of Evolutionary Studies, Japan

Jul.

Invited lectureDevelopment of cancer detecting using olfaction of C. elegans

Hirotsu T.

OPACK(Kyushu University)

Jul.

A novel method for Time- and Cell-specific RNAi reveals the temporal role of Ras in the motor neurons controlling exploratory behavior

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

Neuro2015

Jul.

The analysis of the neuropeptide signaling in the neural circuit-dependent odor adaptation

Ueda N, Matsuo T, Hirotsu T.

Neuro2015

Jul.

A novel method for time- and cell-specific RNAi revealed the profile of Let-60Ras in exploratory behavior

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

International C. elegans meeting

Oct.

Cancer screening test using C. elegans scent detection.

Sonoda H., Hirotsu T.

Japanese Cancer Association

Oct.

Cancer screening test using C. elegans scent detection.

Sonoda H., Hirotsu T., et al

Japan Society of Clinical Oncology

2014
Dec.

Invited PresentationA highly accurate cancer diagnosis system using C. elegans scent detection

Hirotsu T., Sonoda H, Uozumi T, Mimori K, Maehara Y, Hamakawa M

12th ISMNTOP

Dec.

Switching of olfactory receptors depending on odor concentrations in C. elegans

Taniguchi G, Hamakawa M, Uozumi T, Kiriyama K, Kamizaki T, Hirotsu T.

12th ISMNTOP

Dec.

The neural circuit mechanisms regulating olfactory preference change (olfactory central adaptation) after odor experience in C. elegans

Ueda N, Matsuo T, Hirotsu T.

12th ISMNTOP

Dec.

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Deno Y., Hirotsu T.

The Molecular Biology Society of Japan

Nov.

Voltage-dependent anion channel (VDAC-1) is required for olfactory sensing in C. elegans

Uozumi T., Deno Y., Hirotsu T.

The Japanese Association for the Study of Taste and Smell

Nov.

Switching of olfactory receptors depending on odor concentrations in C. elegans

Taniguchi G, Hamakawa M, Uozumi T, Kiriyama K, Kamizaki T, Hirotsu T.

The Japanese Association for the Study of Taste and Smell

Sep.

The neural circuit mechanisms regulating olfactory preference change (olfactory central adaptation) after odor experience in C. elegans

Ueda N, Matsuo T, Hirotsu T.

The Genetics Society of Japan

Jul.

A novel method, time- and cell-specific RNAi, revealed the function of Ras in neurons regulating exploratory behavior oral presentation

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

Neuro2014

Jun.

Analysis of functions of LET-60Ras in regulation of exploratory behavior by a novel method, time- and cell-specific RNAi.

Hamakawa M., Uozumi T., Ueda N., Iino Y., Hirotsu T.

The 6th Asia-pacific C. elegans Meeting

2013
Dec.

The consideration based on the physiological and psychological effects.

Matsuo T., Shimizu K., Okamoto G., Hirotsu T. et al.

The Molecular Biology Society of Japan

Nov.

Invited PresentationThe Ras-MAPK pathway plays multiple roles in the olfactory systems of C. elegans.

Hirotsu T.

World Gene Convention

Jun.

Screening of odor-receptor pairs reveals concentration-dependent switches in olfactory receptors.

Uozumi T., Taniguci G., Kiriyama K., Kamizaki T., Hirotsu T.

Neuro2013

Jun.

The Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M. Iino Y., Hirotsu T.

Neuro2013

Jun.

Invited PresentationThe Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.

Hirotsu T.

World DNA and Genome Day

2012
Dec.

The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.

Hamakawa M., Iino Y., Hirotsu T.

The Molecular Biology Society of Japan

Dec.

The Ras-MAPK pathway plays important roles in the olfactory systems of C. elegans.

Matsuo T., Hirotsu T.

The Molecular Biology Society of Japan

Dec.

Comprehensive analysis of olfactory receptors in C. elegans

Uozumi T., Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Ishihara T., *Hirotsu T.,

The Molecular Biology Society of Japan

Dec.

Systematic identification of specific receptors for odorants in C. elegans.

Matsuo T., Hirotsu T., et al.

The Molecular Biology Society of Japan

Dec.

The Ras-MAPK pathway is important for foraging behavior in C. elegans

Hamakawa M. Iino Y., Hirotsu T.

The Molecular Biology Society of Japan

Dec.

In vivo Imaging Reveals Regulatory Mechanisms and Functions of Ras Activity in Olfactory Neurons

Uozumi T., Hirotsu T., Yoshida K., Yamada R., Suzuki A., Iino Y., Ishihara T.

The Molecular Biology Society of Japan

Sep.

In vivo Imaging Reveals Regulatory Mechanisms and Functions of Ras Activity in Olfactory Neurons

Uozumi T., Hirotsu T., et al.

Neuroscience2012

Sep.

Systematic identification of specific receptors for odorants in C. elegans.

Matsuo T., Hirotsu T.

The Genetics Society of Japan

Sep.

A role for Ras in inhibiting circular foraging behavior as revealed by a new method for time and cell-specific RNAi.

Hamakawa M., Iino Y., Hirotsu T.

The Genetics Society of Japan

Sep.

Screening of Odor-Receptor Pairs in Caenorhabditis elegans Reveals Different Receptors for High and Low Odor Concentrations.

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Hirotsu T.

The Genetics Society of Japan

Jun.

Neuronal mechanisms underlying olfactory preference change depending upon odor concentration

Yoshida K., Hirotsu T., et al.

ISOT(International Symposium on Olfaction and Taste)

Jun.

Systematic identification of olfactory receptors for odorants

Taniguchi G., Kiriyama K., Kamizaki T., Noriko S., and Hirotsu T.

East Asia Worm Meeting

Jun.

In vivo Imaging of Ras Activity in Olfactory Neurons Suggests its Transient Activation is Important for Olfactory Behavior

Uozumi T., Hirotsu T., et al.

East Asia Worm Meeting

2011
Dec.

In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Uozumi T., Hirotsu T., et al.

The Molecular Biology Society of Japan

Dec.

Systematic identification of olfactory receptor for odorants in C. elegans

Taniguchi G., Kiriyama K., Kamizaki T., Sato N., Ishihara T., Hirotsu T.

The Molecular Biology Society of Japan

Sep.

In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Uozumi T., Hirotsu T., et al.

Neuroscience2011

Jun.

In vivo imaging of Ras activity in olfactory neurons suggests its transient activation is important for olfactory behavior

Hirotsu T., et al.

Japan Society for Cell Biology

Jun.

Olfactory preference switch depending on odor concentration is mediated by combinatorial change of acting sensory neurons

Yoshida K., Hirotsu T., et al.

International Worm Meeting

2010
Dec.

Live imaging of Ras activity in olfactory neurons in C. elegans.

Uozumi T., Hirotsu T., et al.

BMB2010

Dec.

Screening of odor-receptor pairs reveals different receptors function depending on odor concentrations.

Hirotsu T. et al.

BMB2010

Aug.

Invited PresentationLive imaging of Ras activity in olfactory neurons in C. elegans.

Hirotsu T., et al.

Imaging Workshop

Jul.

Neural and Behavioral Mechanisms of Response to an Odorant Depending on its Concentration.

Yoshida K., Hirotsu T., et al

East Asia C. elegans Meeting

Jul.

Ascaroside Pheromones Regulate Olfactory Plasticity through the SNET-1 Peptide.

Yamada K., Hirotsu T., et al.

East Asia C. elegans Meeting

Jul.

Live imaging of Ras activity in olfactory systems in C. elegans.

Uozumi T., Hirotsu T., et al.

elegans Neuro

Jul.

Neural and Behavioral Mechanisms of Response to an Odorant Depending on its Concentration.

Yoshida K., Hirotsu T., et al.

elegans Neuro

Jul.

Ascaroside Pheromones Regulate Olfactory Plasticity through the SNET-1 Peptide.

Yamada K., Hirotsu T., et al.

elegans Neuro

2009
Dec.

Live imaging of Ras activity in olfactory neurons in C. elegans.

Uozumi T., Hirotsu T., et al.

The Molecular Biology Socity of Japan

Jan.

Oral presentationInternationalLive imaging of Ras activity in olfactory neurons in C. elegans.

*Hirotsu T., et al.

International Symposium on Cellular Signaling

Jun.

Oral presentationInternationalOlfactory adaptation is regulated by a peptide signal in C. elegans.

Yamada K., Hirotsu T., et al.

International C. elegans Meeting

Jun.

Systematic identification of specific receptors for odorants in C. elegans.

Yamada K., Hirotsu T., et al.

International C. elegans Meeting

Jun.

Live imaging of Ras activity in olfactory neurons in C. elegans.

Hirotsu T., et al.

International C. elegans Meeting

2008
Dec.

Neural circuit-dependent odor adaptation in elegansis regulated by the Ras-MAPK pathway.

Maeda K., Hirotsu T., et al.

BMB2008

2007
Dec.

Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans

Hirotsu T., et al.

BMB2007

Dec.

Mechanisms of neural circuit-dependent olfactory adaptation of C. elegans

Hirae S., Hirotsu T., et al.

BMB2007

Jun.

GPC-1, a G Protein {gamma} Subunit, Regulates Olfactory Adaptation in Caenorhabditis elegans.

Hirotsu T., et al.

Neuro2007

2006
Nov.

GLR-1 glutamate receptor is regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation.

Hirotsu T., et al.

East Asia C. elegans Meeting

Jun.

Glutamate receptors are regulated by the Ras-MAPK pathway in neural circuit-dependent odor adaptation in C. elegans

Hirotsu T., et al.

Neuro2006

2005
Dec.

Mechanisms of neural circuit-dependent olfactory adaptation of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Oct.

Mechanisms of olfactory plasticity of C. elegans: Regulation of localization of glutamate receptors

Hirotsu T., et al.

The Japan Genetics society

Jun.

The Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans

Hirotsu T., et al.

International C. elegans Meeting

2004
Jun.

The Ras-MAPK pathway controls neural circuit-dependent odor adaptation by regulating localization of glutamate receptors in C. elegans

Hirotsu T., et al.

Neuro2004

2003
Dec.

Mechanisms of olfactory plasticity of C. elegans: Regulation of localization of glutamate receptors

Hirotsu T., et al.

The Molecular Biology Society of Japan

Oct.

Mechanisms of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Genetics society

2002
Dec.

Multiple roles of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Jul.

The Ras-MAPK signal transduction pathway is important for olfactory plasticity.

Hirotsu T., et al.

Japanese Worm Meeting

Oct.

Mechanisms of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Genetics society

Jul.

The Ras-MAPK pathway acts in interneurons for olfactory plasticity.

Hirotsu T., et al.

West Coast Worm Meeting

2001
Dec.

Multiple roles of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

2000
Dec.

THE RAS⁄MAP KINASE PATHWAY IS INVOLVED IN OLFACTION IN CAENORHABDITIS ELEGANS.

Hirotsu T., et al.

Annual Meeting of Society for Neuroscience

Dec.

Involvement of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Aug.

The Ras-MAPK signal transduction pathway plays multiple roles in chemotaxis to odorants.

Hirotsu T., et al.

Japanese Worm Meeting

Jun.

Multiple roles for the Ras-MAPK signal transduction pathway in chemotaxis to odorants?

Hirotsu T., et al.

West Coast Worm Meeting

Jun.

Involvement of the Ras-MAPK pathway in olfactory plasticity of C. elegans

Hirotsu T., et al.

The Japan Neuroscience Society

1999
Dec.

Functions of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan

Jul.

Novel functions of the Ras-MAPK signal in neurons of C. elegans.

Hirotsu T., et al.

International C. elegans meeting

1998
Dec.

Involvement of the Ras-MAPK pathway in olfaction of C. elegans

Hirotsu T., et al.

The Molecular Biology Society of Japan